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CN106478692B 以1-(2-吡啶)-9-苄基-β-咔啉为配体的硝酸铜配合物及其合成方法和应用 有权

以1-(2-吡啶)-9-苄基-β-咔啉为配体的硝酸铜配合物及其合成方法和应用
摘要：
本发明公开了一种以1‑(2‑吡啶)‑9‑苄基‑β‑咔啉为配体的硝酸铜配合物及其合成方法和应用。该配合物的结构式如下式(I)所示，其合成方法为：取如下式(II)所示化合物和硝酸铜，溶于极性溶剂中，进行配位反应，即得；其中，所述的极性溶剂为选自甲醇和乙醇中的一种或两种与选自水、丙酮、氯仿、二氯甲烷和N，N‑二甲基甲酰胺中的一种或两种以上的组合。本发明所述的配合物表现出比配体及顺铂更强的抗肿瘤活性，具有较好的潜在药用价值，有望用于各种抗肿瘤药物的制备。式(I)和式(II)所示结构如下：
摘要（英）：

The invention discloses a copper nitrate complex taking 1-(2-pyridine)-9-benzyl-beta-carboline as a ligand as well as a synthesis method and an application of the copper nitrate complex. The structural formula of the complex is shown in the following formula (I). The synthesis method of the complex comprises the steps as follows: the compound as shown in the following formula (II) and copper nitrate are taken and dissolved in a polar solvent for a coordination reaction, and the copper nitrate complex is obtained, wherein the polar solvent is a combination of one or two selected from methanol and ethanol with one or more than two selected from water, acetone, chloroform, dichloromethane and N, N-dimethylformamide. The complex exhibits higher antitumor activity than the ligand and cisplatin, has better potential medicinal value and is expected to be used for preparation of various antitumor drugs. The structures in the formula (I) and the formula (II) are shown in the specification.

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