The invention provides an automobile with an intelligent drag reduction structure and an operation mode of the automobile. The automobile with the intelligent drag reduction structure comprises an automobile body, wherein a front wind direction sensor is arranged at the front end of the automobile body; a plurality of air inlets are formed in the front end of the automobile body; rotatable air guide nozzles are arranged at ports of the air inlets; lifting plates are arranged on openings of the rotatable air guide nozzles; a balancing air opening is formed in the bottom of the automobile body; an opening and closing plate is arranged at the balancing air opening; a rear wind direction sensor is arranged at the rear end of the automobile body; a plurality of air outlets are formed in the rear end of the automobile body; swinging air guide plates are arranged at ports of the air outlets; lifting covers are arranged at the ports of the air outlets; the air inlets communicate with the air outlets through a plurality of air ducts; the plurality of air ducts are arranged on two sides in the automobile body; fans are arranged in the air ducts and are connected with a wind power generator; a storage battery is arranged inside the automobile body; the wind power generator is connected with the storage battery through a circuit; the balancing air opening communicates with the air outlets through a bottom air duct; a water drainage door is arranged at the tail of the bottom air duct; a controller is arranged inside the automobile body.