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发明授权
CN105968199B 抗电压门控钾通道1.3胞外环肽段的单克隆抗体及应用 有权

抗电压门控钾通道1.3胞外环肽段的单克隆抗体及应用
摘要：
本发明公开了一种抗电压门控钾通道1.3胞外环肽段的单克隆抗体及其应用，它由保藏号为CCTCC NO.C201669的杂交瘤细胞株AbM‑F14FTSSCLS0167‑KLH#15所分泌，本发明还公开了所述单克隆抗体的制备方法和应用。本发明的单克隆抗体能特异性地抑制Kv1.3通道的功能，降低血小板胞内钙浓度、抑制血小板活性，从而达到减少或防止血栓形成的目的。
摘要（英）：

The invention discloses an anti-voltage gated potassium channel 1.3 extracellular cyclopeptide fragment monoclonal antibody and application thereof. The monoclonal antibody is secreted by a hybridoma cell strain AbM-F14FTSSCLS0167-KLH#15 of which the collection number is CCTCC NO.C201669. The invention also discloses a preparation method and application of the monoclonal antibody. The monoclonal antibody can specifically inhibit the functions of the Kv1.3 channel, lower the platelet intracellular calcium concentration and inhibit the platelet activity, thereby achieving the goal of reducing or preventing thrombosis.

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