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发明公开
CN105916845A 用于抑制SHP2活性的N-氮杂螺环烷取代的N-杂芳基化合物和组合物 有权

用于抑制SHP2活性的N-氮杂螺环烷取代的N-杂芳基化合物和组合物
摘要：
本发明涉及能够抑制SHP2活性的式I化合物，其中p、q、Y1、Y2、R1、R2a、R2b、R3a、R3b、R4a、R4b、R5a、R5b、R7和R8如发明内容中所定义。发明还提供用于制备本发明化合物的方法、包含此类化合物的药物制剂和使用此类化合物和组合物控制与异常SHP2活性相关的疾病或病症的方法。
摘要（英）：

The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

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