The invention provides an ointment for conditioning perimenopausal syndromes; the ointment is prepared from the following raw materials in parts by weight: 10-20 parts of donkey hide gelatin, 10-20 parts of a tortoise-shell glue, 5-10 parts of Chinese yam, 5-10 parts of Chinese wolfberry, 5-10 parts of mulberry, 5-8 parts of radix puerariae, 5-10 parts of rhizoma polygonati, 3-5 parts of cortex cinnamomi, 5-10 parts of poria cocos, 8-12 parts of semen ziziphi spinosae, 8-12 parts of rhizoma anemarrhenae, 8-12 parts of liquorice, 10-40 parts of walnut kernels, 10-40 parts of black sesame, 10-20 parts of rock sugar, and 20-60 parts of yellow rice wine. The ointment provided by the invention can effectively condition perimenopausal mental and physical states, and improves hectic fever, sweating, heart palpitations, chest distress, waist and neck aching pain, anxiety and other symptoms through blood replenishing and other conditioning.