The invention relates to a method for preparing sorafenib through a one-pot process, and belongs to the field of medical chemistry. The method allows sorafenib to be obtained in a high efficiency manner by changing the feeding mode. The method comprises the following steps: adding 4-chloro-N-methylpyridine-2-carboxamide, p-aminophenol and 4-chloro-3-trifluoromethylphenyl isocyanate or 4-chloro-3-trifluoromethylanilinophenyl carbamate or N-(4-chloro-3-trifluoromethylphenyl)-1H-imidazole-1-amide or N-chloroformyl-4-chloro-3-trifluoromethyl phenylamine in an organic solvent containing an alkali, and reacting at 20-80DEG C to obtain the target product. The method has the advantages of simple operation, short production period, high yield, realization of the purity of the obtained product reaching 97% or above, no need of intermediate separation, and suitableness for industrial production.