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发明公开
CN105283182A 用谷氨酰胺酶的杂环抑制剂治疗癌症 无效 - 驳回

用谷氨酰胺酶的杂环抑制剂治疗癌症
摘要：
本发明涉及新的杂环化合物及其药物制剂以及使用本发明的化合物治疗或预防癌症的方法。其它方面涉及鉴定可获益于用谷氨酰胺酶抑制剂治疗的癌症患者的方法，所述方法包括测定患者的癌细胞中谷氨酸与谷氨酰胺的比率、谷氨酰胺酶与谷氨酰胺合成酶比率或谷氨酰胺酶活性。
摘要（英）：

The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof and the methods of treating or preventing cancer using the compounds of the invention. Other aspects relate to methods of identifying a cancer patient that may benefit from treatment with a glutaminase inhibitor comprising determining the ratio of glutamate to glutamine, the ratio of glutaminase enzyme to glutamine synthetase or glutaminase activity in cancer cells of the patient.

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