The invention discloses a space-time self-coding method for a full-duplex two-way relay network, and aims to solve the problem of low full-duplex system performance and spectral efficiency due to interference of a residual loop in the prior art. The space-time self-coding method disclosed by the invention comprises the following specific steps: firstly, estimating a channel parameter by adopting a minimum mean square error estimation method; secondly, modulating a signal to be sent by adopting a quadrature phase shift keying QPSK method by a terminal node; then, estimating a transmitting signal of the terminal node and performing asynchronous space-time coding by eliminating a loop signal of a relay node; and finally, performing space-time decoding by constructing an equivalent channel matrix on the basis of offset of the loop reference of the terminal node. The space-time self-coding method disclosed by the invention is applied to full-duplex two-way communication and can increase the full-duplex communication reliability; and the spectral efficiency of a cooperative communication system is increased.