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发明公开
CN105218515A 一种药用来那度胺半水合物晶体的制备方法 失效 - 权利终止

一种药用来那度胺半水合物晶体的制备方法
摘要：
本发明涉及一种从来那度胺粗品出发，重结晶制备药用来那度胺半水合物晶体的方法。采用混合溶剂和水进行重结晶，通过控制降温速率和水的量可以很好的得到用于符合制剂要求的半水合结晶产物；所述的混合溶剂体系是甲醇、1，4-二氧六环，N,N-二甲基甲酰胺、乙腈、乙醇、N-甲基吡咯烷酮、异丙醇、丙酮、乙醚、二氯甲烷等两组分和多组分的混合溶剂。
摘要（英）：

The invention relates to a recrystallization method for preparing a medicinal lenalidomide semihydrate crystal from a lenalidomide crude product. A mixed solvent and water are adopted for carrying out recrystallization, and a semihydrate crystallized product for meeting the preparation requirement can be well obtained by controlling the rate of temperature fall and the amount of water; and the mixed solvent system is the mixed solvent of two or more compounds including methyl alcohol, 1,4-dioxane, N,N-dimethyl formamide, acetonitrile, ethyl alcohol, n-methyl pyrrolidone, isopropanol, acetone, diethyl ether, dichloromethane and the like.

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