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发明授权
CN105130722B 1,2,3‑三氮唑单取代1,3,5‑均三嗪类化合物协同CuSO4·5H2O催化脱羧偶联反应的方法 失效 - 权利终止

1,2,3‑三氮唑单取代1,3,5‑均三嗪类化合物协同CuSO<sub>4</sub>·5H<sub>2</sub>O催化脱羧偶联反应的方法
摘要：
本发明公开了一种1,2,3‑三氮唑单取代1,3,5‑均三嗪类化合物协同CuSO4·5H2O催化脱羧偶联反应的方法，该方法以稳定性好、廉价易得的CuSO4·5H2O和对水、空气稳定、高对官能团化的三嗪类化合物为催化体系，催化卤代芳烃与苯丙炔酸的脱羧偶联反应，该反应体系无需使用传统膦配体，减少了环境污染，且具有良好的底物适用性，目标产物易分离纯化并收率高。本发明是一种高效、安全的脱羧偶联反应体系，可应用于一步构筑Csp‑Csp2键。
摘要（英）：

The invention discloses a method for catalyzing decarboxylation coupling reaction by a 1,2,3-triazole monosubstituted 1,3,5-s-triazine compound coordinated with CuSO4.5H2O. By taking CuSO4.5H2O which is good in stability and cheap and easily available and the triazine compound which is stable in water and air and high in functionalization as a catalytic system, the method catalyzes decarboxylation coupling reaction on aryl halide and phenylpropiolic acid. The reaction system is free of a conventional phosphine ligand, so that the environmental pollution is reduced, and the method has good substrate applicability. The target product is easy to separate and purify and high in yield. The method disclosed by the invention is an efficient and safe decarboxylation coupling reaction system and can be applied to constructing Csp-CsP2 bonds.

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