The invention belongs to the field of organic synthesis and in particular relates to a synthetic method of 6-phenyl-8-methoxyethyl formate imidazo[1,2a]pyridine-3-ethyl formate. The synthetic method comprises the steps that 2-amino-3-hydroxy-5-phenylpyridine reacts with DMF-DMA at 35-115 DEG C to prepare an N,N-dimethyl-N'-(5-phenyl-3-hydroxypyridine-2-yl)carboxamidine intermediate which is unnecessary to be purified; the intermediate reacts with ethyl bromoacetate at 55-170 DEG C to generate a crude product of 6-phenyl-8-methoxyethyl formate imidazo[1,2a]pyridine-3-ethyl formate, and the crude product is re-crystallized and purified, thus obtaining pure 6-phenyl-8-methoxyethyl formate imidazo[1,2a]pyridine-3-ethyl formate. The synthetic method has the beneficial effects that the reaction raw materials are easier to obtain; the price is reasonable; the reaction conditions are mild; the synthetic method is easy to operate and control and is simple in after-treatment; the product has stable quality and high purity.