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发明公开
CN105037351A 3,6-二氯咪唑并[1,2-a]吡啶的合成方法 无效 - 撤回

3,6-二氯咪唑并[1,2-a]吡啶的合成方法
摘要：
本发明属于有机合成领域，具体涉及一种 3,6-二氯咪唑并[1,2-a]吡啶的合成方法。包括以下步骤：以2-氨基-5-氯吡啶、氯乙醛水溶液、N-氯代丁二酰亚胺为原料，2-氨基-5-氯吡啶、氯乙醛水溶液二者物质的量之比为1:0.9-3.0，2-氨基-5-氯吡啶与N-氯代丁二酰亚胺物质的量之比为1:0.7-2.5，在适当的溶剂中，于碱的作用下，于35-115℃连续反应生成3,6-二氯咪唑并[1,2-a]吡啶粗产品，经提纯后得到3,6-二氯咪唑并[1,2-a]吡啶纯品。反应原料比较易得，价格合理，反应条件温和，易于操作，易于控制，后处理简单，且产品质量稳定，纯度高。
摘要（英）：

The invention belongs to the field of organic synthesis and in particular relates to a synthetic method of 3,6-dichloroimidazo[1,2-a]pyridine. The synthetic method comprises the following steps: by using 2-amino-5-chloropyridine, a chloroacetaldehyde water solution and N-chlorosuccinimide as raw materials, continuously reacting at 35-115 DEG C in proper solvents under the action of alkali to generate a crude product of 3,6-dichloroimidazo[1,2-a]pyridine and purifying the crude product, thus obtaining pure 3,6-dichloroimidazo[1,2-a]pyridine, wherein the ratio of amount of substance of 2-amino-5-chloropyridine and the chloroacetaldehyde water solution is 1 to (0.9-3.0), and the ratio of amount of substance of 2-amino-5-chloropyridine and N-chlorosuccinimide is 1 to (0.7-2.5). The synthetic method has the beneficial effects that the reaction raw materials are easier to obtain; the price is reasonable; the reaction conditions are mild; the synthetic method is easy to operate and control and is simple in after-treatment; the product has stable quality and high purity.

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