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Invention Publication
CN104711270A 一种重组沙门氏菌SL7207(pVAXD-N-Sa) 无效 - 驳回

一种重组沙门氏菌SL7207(pVAXD-N-Sa)
Abstract:
本发明公开了一种如SEQ ID NO：1所示的核苷酸序列，公开了包含SEQ ID NO：1和SEQ ID NO：2所示核苷酸序列的重组载体、重组菌。本发明包含SEQ ID NO：1和SEQ ID NO：2所示核苷酸序列的重组沙门氏菌SL7207(pVAXD-N-Sa)免疫，可同时诱导产生针对猪传染性胃肠炎病毒(TGEV)的S蛋白和N蛋白的两种特异性抗体，具有双基因的免疫功能，免疫效果更全面，诱导的抗体水平高，可对猪传染性胃肠炎提供更全面的免疫保护作用，临床应用前景优良。
Abstract(English):

The invention discloses a nucleotide sequence represented by SEQ ID NO:1, a recombinant vector containing nucleotide sequences represented by SEQ ID NO:1 and SEQ ID NO:2 respectively, and a recombinant bacterium containing the nucleotide sequences. The recombinant salmonella SL7207 (pVAXD-N-Sa) containing the nucleotide sequences represented by SEQ ID NO:1 and SEQ ID NO:2 respectively is immune, can realize simultaneous inducible formation of transmissible two specific antibodies of the S protein and the N protein of gastro-enteritis virus (TGEV), has double-gene immune functions, comprehensive immune effects and high induced antibody level, can provide comprehensive immune protection effects for the transmissible gastro-enteritis, and has excellent clinic application prospect.

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