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发明公开
CN104693156A 9,10-二羟基-1-去氧紫杉醇类似物及其制备方法 无效 - 撤回

9,10-二羟基-1-去氧紫杉醇类似物及其制备方法
摘要：
本发明涉及一种9,10-二羟基-1-去氧紫杉醇类似物及其制备方法。该类似物的结构式为：其中：R为：甲基苯基、甲氧基苯基、丙基苯基、乙基苯基、氟苯基、甲基氯苯、溴苯基、呋喃基、噻吩基或苯并呋喃基。本发明的9,10-二羟基-1-去氧紫杉醇类似物在7、9、10位上是裸露的羟基，能够大大提高该类化合物的水溶性，13位侧链由各种取代基，丰富了该类化合物，为研究这类化合物活性构效关系鉴定了非常有意义的基础。
摘要（英）：

The invention relates to a 9,10-dihydroxy-1-deoxy-taxol analogue and a preparation method thereof. The structural formula of the analogue is shown in the specification, wherein R is methylphenyl, methoxyphenyl, propylphenyl, ethylphenyl, fluorophenyl, methyl chlorophenyl, bromophenyl, furyl, thienyl or benzofuranyl. The 9,10-dihydroxy-1-deoxy-taxol analogue has exposed hydroxyls on sites 7, 9 and 10, so that the water solubility of compounds can be greatly improved; various substituents are located on a side chain on a site 13, so that the compounds are enriched, and a very important foundation is laid for the authentication of structure-activity relationship of the compounds.

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