知搜-全球专利检索

  1. Login
  2. Sign Up
Invention Publication
CN104220590A 使得工程化的发酵单胞菌在木糖培养基上立即生长的基因失活 无效 - 驳回 复审申请

使得工程化的发酵单胞菌在木糖培养基上立即生长的基因失活
Abstract:
经过基因工程改造以具有破坏的醛糖还原酶基因，使在NADPH存在下将木糖转化为木糖醇的醛糖还原酶活性降低了超过90％的、以及经过工程化改造以表达木糖利用代谢途径的发酵单胞菌(Zymomonas)细胞，被发现具有在包含作为唯一糖类的木糖的培养基上生长而不需在包含木糖的培养基上适应的能力。
Abstract(English):

Zymomonas cells that are genetically engineered to have a disrupted aldose reductase gene such that aldose reductase activity for conversion of xylose to xylitol in the presence of NADPH is reduced by greater than 90%, and that are engineered to express a xylose utilization metabolic pathway, were found to have the ability to gro on medium containing xylose as the only sugar without adaptation in media containing xylose.

Patent Agency Ranking
0/0