The invention belong to the technical field of microbial winemaking, and aims to solve problem that the conventional miscellaneous grain crop liquor is single in varieties, simple in taste, bitter in taste, and pale in aroma, and cannot meet mass consumer tastes. An amaranthus hypochondriacus miscellaneous grain crop health liquor and a making method thereof are provided to improve the edibility of the amaranthus hypochondriacus. The amaranthus hypochondriacus miscellaneous grain crop health liquor is made by pulverizing amaranthus hypochondriacus leaves, black bean, rye, bitter buckwheat, oat, coix seeds and millet, cooking the pulverized mixture, performing fermentation mixed with yeast, performing mixing distillation, and the like. The amaranthus hypochondriacus miscellaneous grain crop health liquor provided by the invention is bright in color, mellow and soft in taste, and unique in taste, has lots of nutritional ingredients and mellow and soft taste, and can meet double requirements of consumers on nutrition and taste; the liquor contains flavonoid compounds, so that oxygen free radicals in a body can be effectively removed, the antioxidant capacity of the liquor is ten times higher than that of the Vitamin E, the degeneration and aging of cells can be prevented, the occurrence of cancer can be prevented, and the immunity of the body can be enhanced; the liquor has an effect of reducing blood fat, blood pressure and blood sugar.