The invention discloses a handling device for cargos in a large ship cabin. The handling device comprises a wharf lifting device and a cabin lifting device. The wharf lifting device and the cabin lifting device are perpendicular to each other, and the top end of the wharf lifting device is close to the top end of the cabin lifting device. A horizontal 90-degree turning machine is installed between the top end of the wharf lifting device and the top end of the cabin lifting device. The cargos in the cabin can be conveyed through the cabin lifting device and transferred to the wharf lifting device through the horizontal 90-degree turning machine to be discharged, and the cargos on a wharf can also be conveyed through the wharf lifting device and transferred to the cabin lifting device through the horizontal 90-degree turning machine to be discharged. The handling device for the cargos in the large ship cabin has the advantages that the arrangement is convenient, operation is easy, the degree of automation is high, the handling efficiency is greatly improved, and the handling device is particularly suitable for handling the cargos in small and medium size cargo ships under the situation that the wharf conditions are poor.