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发明公开
CN103599109A 强的松和羟氯喹在制备复方抗炎药物中的应用 无效 - 驳回

强的松和羟氯喹在制备复方抗炎药物中的应用
摘要：
本发明公开了强的松和羟氯喹在制备复方抗炎药物中的应用，强的松使用总剂量为0.05mg/kg—2mg/kg，羟氯喹使用总剂量为0.83mg/kg—26.64mg/kg。在二甲苯致小鼠耳肿胀实验中，相当于成人正常用量一半的小鼠的强的松等效量的抗炎效果不明显，此剂量的强的松与羟氯喹合用后有明显的抗炎效果。细胞和分子生物学实验表明，羟氯喹与强的松联用能显著抑制LPS诱导的IL-1β和IL-6转录，此种抑制作用均比强的松或羟氯喹单用强。本发明开发了一种新型的复方抗炎药，并为降低强的松治疗的副作用，扩大其应用范围奠定了基础。
摘要（英）：

The invention discloses an application of prednisone and hydroxychloroquine to the preparation of a compound anti-inflammatory drug. The total dose of prednisone is 0.05-2mg/kg, and the total dose of hydroxychloroquine is 0.83-26.64mg/kg. The prednisone for a mouse, the dose of which is equivalent to half of the normal dose of the prednisone for an adult, is unobvious in anti-inflammatory effect in a dimethylbenzene caused mouse ear swelling test, and the prednisone with the dose has an obvious anti-inflammatory effect after being used together with the hydroxychloroquine. Cell and molecular biological tests prove that IL-1beta and IL-6 transcriptions induced by LPS (Lipopolysaccharide) can be remarkably inhibited by the combination of the hydroxychloroquine and the prednisone, and the inhibiting effect is stronger than the inhibiting effect of the prednisone or the hydroxychloroquine. The invention also develops a novel compound anti-inflammatory drug and lays the foundation for reducing the side treating effect of the prednisone and widening the application range of the prednisone.

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