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CN103588718A 作为GABAB受体调节剂的新三嗪二酮衍生物 无效 - 撤回

作为GABAB受体调节剂的新三嗪二酮衍生物
摘要：
本发明提供了式(I)的化合物，其中W1，W2，W3，W4，W5，B，X1，X2，X3，X4，X5，E和L如本文所定义；本发明的化合物为γ氨基丁酸受体-亚型B(“GABAB”)正变构调节剂(增强剂)，它们用于提供治疗或预防疾病或病症的方法，包括治疗焦虑，抑郁症，癫痫症，精神分裂症，认知障碍，痉挛状态和骨骼肌僵硬，脊髓损伤，多发性硬化，肌萎缩性侧索硬化，大脑性麻痹，与可卡因和烟碱相关的神经性疼痛和渴求，惊恐障碍，创伤后应激障碍，急迫性尿失禁，胃食管反流病，过性下食管括约肌松弛，功能性胃肠病和肠易激综合征。
摘要（英）：

The present invention provides novel compounds of formula (I) wherein W1, W2, W3, W4, W5, B, X1, X2, X3, X4, X5, E and L are as defined herein; invention compounds are gamma amino butyrique acid receptor-subtype B ("GABAB") positive allosteric modulators (enhancers), which are useful to provide methods of treating or preventing diseases or disorders, including treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, panic disorder, posttraumatic stress disorders, urge urinary incontinence, gastroesophageal reflux disease, transient lower oesophageal sphincter relaxations, functional gastrointestinal disorders and irritable bowel syndrome.

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