The invention discloses a camostat mesilate orally disintegrating tablet, and a preparation method and new application thereof. The orally disintegrating tablet comprises the components in percentage by weight: 10-30 percent of camostat mesilate serving as a main material, 40-70 percent of a filler, 0-20 percent of an adhesive, 2-10 percent of a disintegrating agent, 2-8 percent of a corrigent, 0-5 percent of a flow aid and 0.5-2.5 percent of a lubricating agent. The preparation can be obtained by a wet granulation tabletting method or a direct powder tabletting method. The invention provides the camostat mesilate orally disintegrating tablet which is convenient to take, has a good taste and a quick response to adaptation diseases, and is particularly suitable for old people and children suffering from dysphagia and patients suffering from mental disease, and the medication compliance of the patients can be greatly improved; meanwhile, not only can a product prepared by the method disclosed by the invention be used for the existing adaptation diseases such as chronic pancreatitis acute episodes and postoperative reflux esophagitis, but also a research shows that the product has a new treating effect on oral mucositis caused by chemotherapy.