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发明公开
CN103172504A 2,7-二甲基-2,4,6-辛三烯-1,8-二醛的合成方法 有权

2,7-二甲基-2,4,6-辛三烯-1,8-二醛的合成方法
摘要：
本发明提供了2，7-二甲基-2，4，6-辛三烯-1，8-二醛的合成方法，所述合成方法包括如下步骤：(1)乙醛二乙基乙缩醛与乙基(1-丙烯基)醚在催化剂的作用下加成得到1，1，3-三乙氧基-2-甲基-丁烷；(2)1，1，3-三乙氧基-2-甲基-丁烷在异喹啉和对甲苯磺酸催化作用下裂解合成得到1-甲氧基-2-甲基-1，3-丁二烯；(3)1-甲氧基-2-甲基-1，3-丁二烯溶在无水乙醇溶剂中与相转移催化剂十六烷基三甲基溴化铵和氯化试剂三氯异氰尿酸合成生成4，4-二乙氧基-3-甲基-1-氯丁烯；(4)4，4-二乙氧基-3-甲基-1-氯丁烯与三苯基膦成盐合成得到膦盐；和(5)膦盐在双氧水作用下并用碳酸钠溶液缩合生成1，1，8，8-四甲基-2，7-二甲基-2，4，6-辛三烯；再在酸性条件下水解合成2，7-二甲基-2，4，6-辛三烯-1，8-二醛。本发明的工艺路线简捷，操作简单，条件温和，收率良好，极具工业价值。
摘要（英）：

The invention provides a synthetic method of 2,7-dimethyl-2,4,6-octytriene-1,8-dialdehyde. The synthetic method comprises the following steps of: (1) carrying out addition action on acetaldehyde diethyl acetal and ethyl(1-propenyl)ether under the action of a catalyst to obtain 1,1,3-triethoxy-2-methyl-butane; (2) cracking 1,1,3-triethoxy-2-methyl-butane under the catalytic actions of isoquinoline and p-toluenesulfonic acid to synthesizing 1-methoxy-2-methyl-1,3-butadiene; (3) dissolving 1-methoxy-2-methyl-1,3-butadiene in an absolute ethyl alcohol solvent to synthesize 4,4-diethoxy-3-methyl-1-chlorobutylene together with a phase transfer catalyst hexadecyl trimethyl ammonium bromide and a chloride agent trichloroisocyanuric acid; (4) carrying out salifying synthesis on 4,4-diethoxy-3-methyl-1-chlorobutylene and triphenylphosphine to obtain phosphonium salt; and (5) condensing the phosphonium salt with sodium carbonate solution under the action of hydrogen peroxide to generate 1,1,8,8-tetramethyl-2,7-dimethyl-2,4,6-octytriene and carrying out hydrolysis under the acidic condition to synthesize 2,7-dimethyl-2,4,6-octytriene-1,8-dialdehyde. The synthetic method is simple and direct in process route, is simple to operate, is mild in conditions and good in yield and has high industrial value.

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