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CN102886070A 海藻酸钠-壳聚糖皮肤组织工程支架材料及其制备方法 无效 - 撤回

海藻酸钠-壳聚糖皮肤组织工程支架材料及其制备方法
摘要：
本发明涉及一种海藻酸钠-壳聚糖皮肤组织工程支架材料及其制备方法。该支架材料的结构为：海藻酸钠-壳聚糖以CaCl2作为交联剂形成支架基体，其中海藻酸钠和壳聚糖的质量比为5:3～3:5；海藻酸钠形成的网格状结构，经CaCl2交联，以夹层形式置于海藻酸钠-壳聚糖支架基体中；其中网格状的海藻酸钠的网格尺寸为1～2×1～2mm、厚度为0.2～0.5mm。本发明采用可完全生物降解的海藻酸钠、壳聚糖为基材，其中RP技术制备的夹层的复合可提高海藻酸钠-壳聚糖支架材料的力学强度。该支架的孔径在100-150μm，孔隙率大于90%，拉伸强度达到1～8MPa，且该支架材料具有良好的生物相容性，适合细胞的生长及增殖。
摘要（英）：

The invention relates to a sodium alginate and chitosan skin tissue engineering scaffold material and a preparation method thereof. According to the scaffold material, sodium alginate and chitosan take CaCl2 as a crosslinking agent to form a scaffold base, and the mass ratio of the sodium alginate to the chitosan is 5:3-3:5; and a grid structure formed by the sodium alginate is crosslinked by the CaCl2 and put on a sodium alginate and chitosan scaffold base in an interlayer mode, the grid size of the sodium alginate is (1-2)*(1-2)mm<2>, and the height is 0.2 to 0.5mm. By the scaffold material, the sodium alginate and the chitosan base which can be completely degraded are taken as base materials; by combining an interlayer manufactured by a rapid prototyping (RP) technology, the mechanical strength of the sodium alginate and chitosan scaffold material can be improved; and the pore diameter of a scaffold is 100 to 150mu m, the porosity is more than 90 percent, and the tensile strength reaches 1 to 8 MPa. The scaffold material has high biocompatibility and is suitable for growth and proliferation of cells.

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