知搜-全球专利检索

  1. 登录
  2. 注册
发明公开
CN101932584A 作为PI3K阻滞剂的吡咯并嘧啶衍生物及其用途 失效 - 放弃专利权

作为PI3K阻滞剂的吡咯并嘧啶衍生物及其用途
摘要：
本发明提供一种增殖性疾病例如癌症的预防或治疗剂，其具有优异的PI3K阻滞效果、具有细胞增殖阻滞作用、同时在体内的稳定性及水溶解性优异。一种化合物或其医药学上允许的盐，其用式(I)表示，式(I)：[式中，Q表示-X-Y-表示的连结基；X表示单键、-CO-、-CONH-、-CON(C1-4烷基)-、-CS-、-CSNH-、-CSN(C1-4烷基)-、或-SO2-；Y表示单键、亚芳基或杂亚芳基；其中，X和Y不同时为单键；R1表示-C0-6亚烷基-(A)m-C1-6烷基或-C0-6亚烷基-(A)m-C0-6亚烷基-(杂环)]。
摘要（英）：

Disclosed is a prophylactic or therapeutic agent for proliferative diseases including cancer, which has an excellent inhibitory effect on PI3K, an inhibitory activity on the proliferation of a cell, excellent stability in vivo and excellent dispersivility in water. Specifically disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In formula (I), Q represents a linking group represented by -X-Y-; X represents a single bond, -CO-, -CONH-, -CON(C1-4 alkyl)-, -CS-, -CSNH-, -CSN(C1-4 alkyl)- or -SO2-; Y represents a single bond, an arylene or a heteroarylene; provided that X and Y do not represent a single bond simultaneously; and R1 represents -C0-6-alkylene-(A)m-C1-6-alkyl or -C0-6-alkylene-(A)m-C0-6- alkylene-(hetero ring).

0/0