The invention relates to a steel pipe concrete flange combining beam with a concrete fender. A web is arranged in the length direction of a lower fender; the front surface and the back surface of the web are provided with stiffening ribs; the upper end of the web is provided with a steel pipe concrete upper flange formed by pouring self-compacting concrete in a steel pipe; and the upper end of a rectangular steel pipe concrete upper flange is provided with a concrete upper fender. The steel pipe of the rectangular steel pipe concrete upper flange is a rectangular steel pipe, and the cross section is in a rectangular annular shape. The web is in a trapezoidal waveform or sinusoidal waveform or planform shape. The invention can replace the traditional hot rolling I-steel and H-steel combining beam and a welding I-steel combining beam, has the advantages of convenient construction, light deadweight, large bearing capacity, high torsion rigidity, high ductility, and the like, is a combining structure which can fully exert the advantages of two materials of structural steel and high-performance concrete and has favorable application prospect in bridge and structure engineering.