The invention discloses a mesoporous silicon dioxide molecular sieve with elliptic appearance and a preparation method thereof. An industrialized nonionic surfactant is used as a template agent, an organic silicon source is used as a precursor, and the mesoporous silicon dioxide molecular sieve is prepared through synergy of the surfactant and inorganic substances in an acid medium and a hydrothermal treatment process in the presence of multiple additives such as inorganic salt, organic alcohol and the like. The obtained mesoporous silicon dioxide molecular sieve has elliptic regular appearance. The axial ratio of a long axis to a short axis of an ellipsoid is adjustable between 1.0 and 5.0, the aperture of the elliptic mesoporous silicon dioxide molecular sieve is between 6 and 12 nanometers, the pore volume is between 0.8 and 2.0 cm<3>/g, and the specific surface area is between 400 and 1,000 cm<2>/g. The method has the advantages of easily obtained raw materials, simpler process requirements and feasible operation, and is suitable for industrialized large-scale production.