The invention discloses an agricultural high-clearance pesticide spray truck, which comprises a rack. Driving wheels and steering wheels are arranged at the lower part of the rack. An engine, a power transmission mechanism and a front wheel steering mechanism are arranged on the rack. The engine is connected with the driving wheels in a driving way through the power transmission mechanism. The vertical distance from the bottom end of the driving wheels and the steering wheels to the lower surface of the frame is no less than 1.5m. A pesticide spray mechanism is arranged at the rear part of the frame and is connected with the power transmission mechanism in a driving way. The design is novel and the structure is compact; four driving wheels and two foldable wheels are adopted, the width of each wheel is less than the single space for planting wheat and the narrow wheels can run in the space of wheat when pesticide is sprayed; no tractor is used for traction, the chassis of the truck is higher than the height of wheat, the wheels and the chassis do not overwhelm or blow down wheat when the truck runs for spraying pesticide, and the damage to wheat is decreased to zero; and the space of the wheels on the two sides is adjustable and the truck can be used for the field management of the wheat differently spaced in different areas.