The invention relates to a leaching rate prediction and optimization operation method in the wet metallurgical leaching process. The method comprises the following steps: predicting a leaching rate by an established mixing model and giving optimization operation instructions, wherein an integrative dynamic mechanism model of the leaching process is established, and a material balance equation andan energy balance equation are gradually established in the leaching process on the basis of the ore-leaching dynamic principle of the integrative dynamic mechanism model. The device comprises a leaching rate prediction and optimization operation system in the leaching process, a host computer, a PLC and a field sensing transmitting part which comprises a pH value detecting instrument, a temperature detecting instrument, a flow detecting instrument, and the like. With the technical scheme, the leaching process can be greatly improved, the production can be constantly kept in an optimal state,the consumption of raw materials and energy sources is reduced, the operation period of equipment is prolonged and the relation change between supply and demand on markets can be reflected in time.