An intelligent blind guiding system based on high precision positioning comprises four parts such as an intelligent blind guiding call center, a high precision GPS receiver, a high precision urban road space database and an intelligent blind guiding instrument; wherein, the intelligent blind guiding call center internally establishes the connection with the high precision urban road space database and externally establishes the connection with the intelligent blind guiding instrument; the high precision GPS receiver is in charge of receiving GPS satellite signals and resolving high precision latitude and longitude position data and establishes the connection with the intelligent blind guiding instrument by bluetooth communication; the intelligent blind guiding instrument establishes connection with the intelligent blind guiding call center by CDMA communication; the intelligent blind guiding call center can receive the intelligent blind guiding instrument and conduct call and answer in a wireless manner. The system adopts high precision positioning to obtain the positioning data of blind persons, forms pertinent blind guiding information by data processing, conducts broadcasting in the form of speech engine and provides blind persons with omnibearing, accurate and specific blind guiding services in terms of trip.