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发明公开
CN101508693A 一类木质素黄酮类化合物及其制备方法和药物用途 无效 - 撤回

一类木质素黄酮类化合物及其制备方法和药物用途
摘要：
本发明涉及一类木质素黄酮类化合物及其制备方法和药物用途，具体而言，本发明涉及一类B环二氧六环的木质素黄酮类化合物的制备方法及其用于制备抗氧化剂药物的用途。该类化合物具有强效抑制黄嘌呤氧化酶活性，可以预期发展成为防治由黄嘌呤氧化酶引起的痛风病的药物。该类化合物还表现出很强的对抗自由基引起的PC12细胞损伤作用，可以预期发展成为防治老年性痴呆症的药物。本发明的化合物还具有体外抗自由基、保护肝细胞减轻双氧水导致损伤的作用，因此可以预期成为治疗由自由基引起的各种疾病之药物尤其是防治肝脏损伤类药物用途。
摘要（英）：

The invention relates to a series of lignin flavonoid compounds as well as a preparation method and drug use thereof, in particular to a preparation method of a series of beta-cyclodioxane lignin flavonoild compounds and use thereof for preparing antioxidant drugs. The compounds have strong activity of inhibiting xanthine oxidase, and can be expected to be developed into drugs for preventing and treating gout diseases resulting from the xanthine oxidase. The compounds also exhibit strong effects of protecting against PC12 cell injury resulting from free radicals, and can be expected to be developed into drugs for preventing and treating senile dementia. The compounds also have the effects of protecting against free radicals in vitro, protecting hepatic cells and relieving injury resulting from hydrogen peroxide, thus being capable of being expected to be developed into drugs for treating various diseases resulting from the free radicals, especially the use of drugs for preventing and treating liver injury.

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