公开(公告)号：US20250060345A1

公开(公告)日：2025-02-20

申请号：US18452294

申请日：2023-08-18

Applicant: Thermo Finnigan LLC

Inventor： Deven Lee Shinholt

IPC: G01N30/86 ,  G01N27/623 ,  H01J49/00

Abstract: Systems or techniques are provided for facilitating idle-triggered diagnostics for scientific instruments. In various embodiments, a scientific instrument can comprise a mass spectrometer coupled to a chromatograph. In various aspects, the scientific instrument can determine, via a temperature sensor of the chromatograph or via a clock of the mass spectrometer, whether the scientific instrument is in an idle-time period. In various instances, the scientific instrument can, in response to a determination that the scientific instrument is in the idle-time period, apply one or more electronic control signals to the mass spectrometer or to the chromatograph, measure one or more resultant ion spectra via an ion detector of the mass spectrometer, and determine whether the mass spectrometer or the chromatograph is operating correctly based on the one or more resultant ion spectra.

公开(公告)号：US12203885B2

公开(公告)日：2025-01-21

申请号：US17759787

申请日：2021-01-29

Applicant: PHYTRONIX TECHNOLOGIES INC.

Inventor： Pierre Picard ,  Serge Auger

IPC: G01N27/623 ,  G01N27/624

Abstract: Laser diode thermal desorption coupled with tandem mass spectrometry systems and methods are described to detect at least one target analyte in a sample by negative ion mode mass spectrometry. For instance, the system and method involve desorbing a sample prepared for mass spectrometry analysis by laser diode thermal desorption to obtain a desorbed sample, and then ionizing the desorbed sample under conditions to generate an ionized analyte flow comprising a superoxide radical anion (O2.−) adduct detectable by negative ion mode mass spectrometry; and then detecting the O2.− adduct by negative ion mode mass spectrometry, to thereby detect the target analyte.

公开(公告)号：US20250020613A1

公开(公告)日：2025-01-16

申请号：US18787526

申请日：2024-07-29

Applicant: ATONARP INC.

Inventor： Naoki TAKAHASHI

IPC: G01N27/623 ,  H01J49/04 ,  H01J49/10 ,  H01J49/42

Abstract: A gas analyzing apparatus includes: an ionization device that generates an ion flow of a sample gas; an analyzer that analyzes the ion flow supplied from the ionization device; a first ion path that non-linearly guides the ion flow from the ionization device to an inlet of the analyzer; and a blocking device for intermittently blocking and releasing, using an electric field or a magnetic field, the ion flow on at least part of a path of the ion flow through the first ion path to a mass filter of the analyzer. It is possible to perform measurement in a state where the ion flow is blocked and measurement in a state where the ion flow is not blocked.

公开(公告)号：US12165862B2

公开(公告)日：2024-12-10

申请号：US17610843

申请日：2020-05-13

Applicant: Micromass UK Limited

Inventor： Edward Scott ,  Peter Kerr ,  Stephen O'Brien

IPC: H01J49/06 ,  G01N27/623 ,  H01J49/00 ,  H01J49/40

Abstract: An aperture plate assembly for an analytical instrument comprises a first sub-assembly comprising an aperture plate and a second sub-assembly comprising a guide. The first sub-assembly is configured to be attached to the second sub-assembly such that the aperture plate is positioned in a first position relative to the second sub-assembly. The first sub-assembly and the second sub-assembly are configured such that when the first sub-assembly is engaged by the guide, the aperture plate can be moved into the first position and the first sub-assembly can be attached to the second sub-assembly.

公开(公告)号：US20240395523A1

公开(公告)日：2024-11-28

申请号：US18793315

申请日：2024-08-02

Applicant: Micromass UK Limited

Inventor： Jason Lee Wildgoose ,  Keith Richardson ,  David J. Langridge ,  Martin Raymond Green ,  Steven Derek Pringle

IPC: H01J49/00 ,  G01N27/62 ,  G01N27/623 ,  H01J49/42

Abstract: A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

公开(公告)号：US12154772B2

公开(公告)日：2024-11-26

申请号：US17641662

申请日：2020-09-29

Applicant: SHIMADZU CORPORATION

Inventor： Kenichi Mishima ,  Kengo Takeshita

IPC: H01J49/16 ,  H01J49/00 ,  G01N27/623

Abstract: The present invention provides an imaging mass spectrometer which generates ions by irradiating a sample with a laser beam and performs mass spectrometry of the ions, the imaging mass spectrometer including: a laser irradiation unit 30 configured to emit the laser beam toward the sample, a condensing optical system 33 disposed between the laser irradiation unit 30 and the sample and configured to condense the laser beam emitted from the laser irradiation unit 30, an image acquiring unit 40 configured to acquire a condensing state checking image which is an optical microscopic image capable of checking a condensing state on the sample of the laser beam emitted from the laser irradiation unit 30, and a display unit 64 configured to display the condensing state checking image acquired by the image acquiring unit 40 on a display screen.

公开(公告)号：US12094702B2

公开(公告)日：2024-09-17

申请号：US17621584

申请日：2020-05-27

Applicant: HANGZHOU WELL-HEALTHCARE TECHNOLOGIES CO., LTD.

Inventor： Jianmin Wu ,  Xiaoming Chen

IPC: H01J49/04 ,  G01N27/623 ,  G01N27/64

CPC classification number: H01J49/0418 ,  G01N27/623 ,  G01N27/64

Abstract: The present disclosure discloses a silicon nanowire chip and silicon nanowire chip-based mass spectrometry detection method. The detection method includes the following steps: step 1 of manufacturing a silicon nanowire chip, comprising: subjecting a monocrystalline silicon wafer to a surface washing pretreatment, a metal-assisted etching and a post-alkali etching to obtain a silicon nanowire chip with a tip, and performing a surface chemical modification or a nanomaterial modification on the silicon nanowire chip; step 2 of evaluating mass spectrometry performance of the silicon nanowire chip; and step 3 of performing a tip-contact sampling and in-situ ionization mass spectrometry detection.

公开(公告)号：US12092608B2

公开(公告)日：2024-09-17

申请号：US17792170

申请日：2020-03-12

Applicant: SHIMADZU CORPORATION

Inventor： Hidenori Takahashi

IPC: H01J49/14 ,  G01N27/623 ,  G01N27/626

CPC classification number: G01N27/623 ,  G01N27/626 ,  H01J49/14

Abstract: An ion analysis device 1 configured to generate and analyze product ions from precursor ions derived from a sample component includes: a reaction chamber 132 into which the precursor ions are introduced; a radical emitter 134 made of a predetermined kind of metal and disposed in the reaction chamber or a space communicating with the reaction chamber, at least a part of a surface of the radical emitter being oxidized or nitrided; a heating unit 20 configured to heat the radical emitter to a predetermined temperature; and separation detection units 135 and 136 configured to separate and detect, according to at least one of a mass-to-charge ratio and an ion mobility, product ions generated from the precursor ions by a reaction with radicals emitted from the radical emitter heated to the predetermined temperature.

公开(公告)号：US20240272121A1

公开(公告)日：2024-08-15

申请号：US18569701

申请日：2022-06-16

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Bradley B. SCHNEIDER ,  Leigh BEDFORD ,  Yves LE BLANC ,  Eva DUCHOSLAV

IPC: G01N27/623 ,  G01N27/624 ,  H01J49/00

CPC classification number: G01N27/623 ,  G01N27/624 ,  H01J49/0031

Abstract: An automated method of operating a mass spectrometer (MS) comprising a differential mobility spectrometer (DMS) includes: introducing a first compound to the DMS; calculating a first alpha function for the first compound; introducing a second compound to the DMS; calculating a second alpha function for the second compound; and determining operation parameters of the DMS to achieve sufficient separation of the first compound and the second compound, based on the first alpha function and the second alpha function.

公开(公告)号：US20240168008A1

公开(公告)日：2024-05-23

申请号：US18512652

申请日：2023-11-17

Applicant: Diagnose Early, Inc.

Inventor： Chris Wheeler ,  Karl-Magnus Larsson ,  Luke Clauson

IPC: G01N33/497 ,  G01N27/623

CPC classification number: G01N33/497 ,  G01N27/623 ,  G01N2033/4975

Abstract: Methods of assaying a breath sample from a subject for the presence of one or more PFAS are provided. Embodiments of the methods further include providing a composite score that can be used to determine if the subject has been exposed to PFAS and to monitor changes in PFAS exposure over time in the subject. In certain embodiments, a machine learning model may be used to determine if a subject has been exposed to one or more PFAS. The machine learning model may be trained by: analyzing breath samples from a plurality of subjects with a secondary electrospray ionization-high-resolution mass spectrometry analyzer to generate breath assay data; obtaining PFAS exposure data for each subject; training a machine learning model to identify a relationship between the breath samples and PFAS exposure using the breath assay data and the obtained PFAS exposure data; and applying the trained machine learning model to breath assay data, different from the breath assay data used to train the model, to generate a composite score regarding the PFAS exposure for a subject or subjects. In some embodiments, a health evaluation is generated for the subject using the composite score. Also provided are systems for use in practicing methods of the invention.