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公开(公告)号：US20240360238A1
公开(公告)日：2024-10-31
申请号：US18626765
申请日：2024-04-04
发明人： Bradley R. Pearse , Michael Cooke , Anthony Boitano , Rahul Palchaudhuri , Sean McDonough , Rajiv Panwar , Jacob Glanville
IPC分类号： C07K16/28 , A61K35/12 , A61K35/545 , A61K38/00 , A61K39/00 , A61K47/68 , A61P35/00 , A61P37/06 , C07K7/64
CPC分类号： C07K16/2896 , A61K35/545 , A61K47/6817 , A61K47/6831 , A61K47/6849 , A61P35/00 , A61P37/06 , C07K7/64 , C07K16/2803 , A61K2035/124 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/71 , C07K2317/73 , C07K2317/92 , C07K2317/94
摘要： The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. Described herein are antibodies, antigen-binding fragments, and conjugates thereof that can be applied to effect the treatment of these conditions, for instance, by depleting a population of CD117+ cells in a patient, such as a human. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting a population of CD117+ cancer cells or autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.
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公开(公告)号：US20240358845A1
公开(公告)日：2024-10-31
申请号：US18560080
申请日：2022-05-09
发明人： Ziqing Qian , Patrick Dougherty , Mahboubeh Kheirabadi , Haoming Liu , Xiulong Shen , Xiang Li
IPC分类号： A61K47/64 , A61K31/7088 , A61K38/00 , A61P21/00 , C07K7/06 , C07K7/64 , C07K19/00 , C12N15/113
CPC分类号： A61K47/6455 , A61K31/7088 , A61P21/00 , C07K7/06 , C07K7/64 , C07K19/00 , C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/3513
摘要： Provided herein are compounds that include a cyclic cell penetrating peptide, a therapeutic moiety and a modulatory peptide, wherein the modulatory peptide modulates the tissue distribution and/or retention of the compound in vivo. Also provide herein are methods of modulating tissue distribution and/or retention of intracellular therapeutics using the aforementioned compounds.
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公开(公告)号：US12122811B2
公开(公告)日：2024-10-22
申请号：US17045728
申请日：2019-04-05
IPC分类号： C07K14/475 , C07K7/64
CPC分类号： C07K14/475 , C07K7/64
摘要： Provided herein are peptide amphiphiles (PAs) and supramolecular PA nanostructures that mimic brain derived neurotrophic factor (BDNF), a growth factor that induces neuronal survival, maturation, and increased electrical activity. In particular, injectable biomaterials comprising BDNF mimetic PAs are provided, as well as methods of using BDNF mimetic PAs for the treatment or prevention of neurological injuries, diseases, and disorders.
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公开(公告)号：US20240336653A1
公开(公告)日：2024-10-10
申请号：US18007626
申请日：2021-05-19
发明人： Xianxing JIANG , Rui WANG , Nazi SONG
摘要： The present invention relates to peptide compound targeting elastin-derived peptides and use thereof. The peptide comprises a parent peptide represented by the following amino acid sequence: R1-Val-Xa2-Gly-Ser-Pro-Ser-Ala-Gln-Xa9-Xa10-Ala-Ser-Pro-Xa14, and is characterized by better biological activity, higher safety and stability, high synthesis yield, low cost, etc. The peptide compound may be used for treating hepatic fibrosis and fibrotic conditions accompanying hepatic disease as well as idiopathic pulmonary fibrosis and fibrotic conditions accompanying pulmonary disease.
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5.发明公开公开(公告)号：US20240327464A1
公开(公告)日：2024-10-03
申请号：US18289027
申请日：2023-02-10
申请人： C-BIOMEX CO., LTD.
发明人： Song Gil Lee , Hye Sook Ha , Jin Hwi Park , Se Won Kim , Yoo Joung Oh , Seo Hyun Park , Shin Young Park , Jun Hoe Cha
CPC分类号： C07K7/64 , A61K47/64 , A61K49/0056 , A61K51/088 , A61P35/00 , C07K1/1077
摘要： The present invention relates to a peptide ligand that specifically binds to carbonic anhydrase IX (CAIX), a peptide construct comprising the ligand, and a use thereof. The CAIX-binding peptide ligand of the present invention includes D-amino acids, so it is stable in the body and has high binding specificity to CAIX. And the linear or cyclic CAIX-binding peptide construct comprising the ligand can bind to CAIX with high affinity in the body. Therefore, it is useful for diagnosis, prevention, suppression or treatment of diseases mediated by CAIX.
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公开(公告)号：US20240299599A1
公开(公告)日：2024-09-12
申请号：US18515076
申请日：2023-11-20
发明人： Dexing ZENG , Lingyi SUN , Yongkang GAI
IPC分类号： A61K51/08 , A61K9/51 , A61K47/68 , A61K51/10 , C07D255/02 , C07D257/02 , C07K7/06 , C07K7/64 , C07K16/30 , G01N33/50 , G01N33/60
CPC分类号： A61K51/082 , A61K9/51 , A61K47/6893 , A61K51/1027 , C07D255/02 , C07D257/02 , C07K7/06 , C07K7/64 , C07K16/30 , G01N33/5008 , G01N33/60 , C07K2319/00
摘要： The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.
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公开(公告)号：US20240279282A1
公开(公告)日：2024-08-22
申请号：US18433043
申请日：2024-02-05
CPC分类号： C07K7/64 , C07K5/126 , C08G73/1096
摘要： Disclosed is a cyclic peptide polymer having the below structure. Each R1 and each R2 is an organic group. Each R3 is a covalent bond or methylene. The values m and n are nonnegative integers having a sum of at least 1. Each X is —NH—CO— or —CO—N—. The value p is an integer greater than 1. The cyclic peptide polymer may be made by providing a cyclic peptide having two side chains having terminal amino groups or carboxylic acid groups, and reacting the amino groups with an azobenzene or the carboxylic acid groups with an azodianiline.
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8.发明公开公开(公告)号：US20240270794A1
公开(公告)日：2024-08-15
申请号：US18568148
申请日：2022-06-10
申请人： FUTURECHEM CO., LTD.
发明人： Dae Yoon CHI , Keumrok OH
CPC分类号： C07K7/64 , A61K51/08 , C07B59/008
摘要： The 18F-ApoPep-7 of chemical formula 1 according to the present invention, which is a derivative of 18F-ApoPep-1, has the manufacturing advantage of labeling the radioisotope F-18 with high radiochemical yield, radiochemical purify, and high specific radioactivity. Therefore, when used as an imaging drug for positron emission tomography, the 18F-ApoPep-7 of the present invention can be applied to the diagnosis of various diseases associated with apoptosis.
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公开(公告)号：US20240124526A1
公开(公告)日：2024-04-18
申请号：US18394401
申请日：2023-12-22
摘要： Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
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公开(公告)号：US11946086B2
公开(公告)日：2024-04-02
申请号：US17549492
申请日：2021-12-13
申请人： NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , TOHOKU UNIVERSITY , KUMIAI CHEMICAL INDUSTRY CO., LTD.
发明人： Takashi Kubo , Masayuki Machida , Maiko Umemura , Keietsu Abe , Akira Yoshimi , Tomonori Fujioka , Shigenari Yamaguchi , Kiyoshi Kawai
摘要： This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.
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