公开(公告)号：US11111252B2

公开(公告)日：2021-09-07

申请号：US16947651

申请日：2020-08-11

Applicant: Duquesne University of the Holy Spirit

Inventor： Aleem Gangjee

IPC: C07D487/04 ,  C07D495/04 ,  A61K31/343 ,  C07D403/02 ,  A61K31/505 ,  C07D405/02 ,  A61K31/4709 ,  C07D239/48

Abstract: The present invention discloses a compound of the formula: and optionally comprising a pharmaceutically acceptable salt or hydrate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt or hydrate thereof.

公开(公告)号：US20210032256A1

公开(公告)日：2021-02-04

申请号：US17010089

申请日：2020-09-02

Applicant: Grünenthal GmbH

Inventor： Sven KUEHNERT ,  Rene KOENIGS ,  Achim KLESS ,  Anita WEGERT ,  Ingo KONETZKI ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC: C07D487/04 ,  C07D403/04 ,  C07D235/02 ,  C07D401/04 ,  C07D409/14 ,  C07D405/06 ,  C07D403/14 ,  C07D413/14 ,  C07D417/04 ,  C07D405/14 ,  C07D401/14 ,  C07D471/04 ,  C07D405/02 ,  C07D401/02 ,  C07D413/02 ,  C07D409/04

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10886474B2

公开(公告)日：2021-01-05

申请号：US15509590

申请日：2015-09-25

Applicant: Rohm and Haas Electronic Materials Korea Ltd.

Inventor： Doo-Hyeon Moon ,  Jeong-Eun Yang ,  Hee-Ryong Kang ,  Young-Mook Lim ,  Ji-Song Jun ,  Hee-Choon Ahn ,  Jin-Ri Hong ,  Su-Hyun Lee ,  Bitnari Kim ,  Tae-Jin Lee

IPC: C07D209/56 ,  C07D209/88 ,  C07D209/86 ,  C07D209/82 ,  C07D405/02 ,  C07D405/10 ,  C07D405/04 ,  C07D409/02 ,  C07D409/10 ,  C09K11/06 ,  H01L51/00 ,  C07D409/04 ,  H01L51/50

Abstract: The present disclosure relates to an organic electroluminescent compound, and an organic electroluminescent material and an organic electroluminescent device comprising the same. The organic electroluminescent compound of the present disclosure has excellent color purity, solubility, and thermal stability. By comprising the organic electroluminescent compound and the organic electroluminescent material of the present disclosure, an organic electroluminescent device showing low driving voltage, excellent current and power efficiencies, and significantly improved lifespan can be provided.

公开(公告)号：US20190375754A1

公开(公告)日：2019-12-12

申请号：US16450331

申请日：2019-06-24

Applicant: Grünenthal GmbH

Inventor： Sven KUEHNERT ,  Rene KOENIGS ,  Achim KLESS ,  Anita WEGERT ,  Ingo KONETZKI ,  Paul RATCLIFFE ,  Ruth JOSTOCK ,  Thomas KOCH ,  Klaus LINZ ,  Wolfgang SCHROEDER

IPC: C07D487/04 ,  C07D409/04 ,  C07D413/02 ,  C07D401/02 ,  C07D405/02 ,  C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/06 ,  C07D409/14 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10377719B2

公开(公告)日：2019-08-13

申请号：US15945429

申请日：2018-04-04

Applicant: Hoffmann-La Roche Inc.

Inventor： Maude Giroud ,  Wolfgang Haap ,  Bernd Kuhn ,  Rainer E. Martin

IPC: A61P33/02 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/421 ,  A61K31/4192 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/443 ,  A61K31/4439 ,  C07D231/14 ,  C07D263/34 ,  C07D405/02 ,  C07D249/06 ,  C07D401/04 ,  C07D403/02 ,  C07D261/18 ,  C07D271/06 ,  C07D271/10 ,  C07D401/12 ,  C07D213/56 ,  C07D403/04 ,  C07D407/04 ,  C07D261/10 ,  C07D405/04

Abstract: The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US20190106429A1

公开(公告)日：2019-04-11

申请号：US16207854

申请日：2018-12-03

Applicant: GRUENENTHAL GMBH

Inventor： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D487/04 ,  C07D409/04 ,  C07D401/02 ,  C07D405/02 ,  C07D471/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D413/14 ,  C07D403/14 ,  C07D405/06 ,  C07D409/14 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04 ,  C07D413/02

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US10174068B2

公开(公告)日：2019-01-08

申请号：US14416996

申请日：2013-07-26

Applicant: BIOMERIEUX

Inventor： Thomas Cailly ,  Frédéric Fabis ,  Ali Laayoun ,  Alain Laurent ,  Sylvain Ursuegui

IPC: C07H21/02 ,  C07D405/02 ,  C07D213/80 ,  C07D495/04 ,  C07D519/00 ,  C07H1/00 ,  C12Q1/6825

Abstract: The present invention relates to a method of functionalization of at least one ribonucleic acid (RNA) molecule, contained in a liquid sample, which includes the following steps: a) providing at least: one binding molecule consisting of an aza-isatoic anhydride or a derivative thereof, one group of interest, and one linkage joining the binding molecule to the group of interest, b) reacting the anhydride function of the binding molecule with at least one hydroxyl group carried: in position 2′ of the ribose of one of the RNA nucleotides, and/or in position(s) 2′ and/or 3′ of the ribose of the nucleotide at the terminal 3′ end of the RNA, and obtaining an aza-anthranilate that joins, by means of the linkage, the RNA to the group of interest.

公开(公告)号：US20180201616A1

公开(公告)日：2018-07-19

申请号：US15923948

申请日：2018-03-16

Applicant: Gruenenthal GmbH

Inventor： Sven Kuehnert ,  Rene Koenigs ,  Achim Kless ,  Anita Wegert ,  Ingo Konetzki ,  Paul Ratcliffe ,  Ruth Jostock ,  Thomas Koch ,  Klaus Linz ,  Wolfgang Schroeder

IPC: C07D487/04 ,  C07D471/04 ,  C07D235/02 ,  C07D413/14 ,  C07D413/02 ,  C07D409/14 ,  C07D409/04 ,  C07D405/14 ,  C07D405/06 ,  C07D405/02 ,  C07D403/14 ,  C07D403/04 ,  C07D401/14 ,  C07D401/04 ,  C07D401/02 ,  C07D417/04

CPC classification number: C07D487/04 ,  C07D235/02 ,  C07D401/02 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/02 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/02 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04

Abstract: The invention relates to 3-((hetero-)aryl)-8-amino-2-oxo-1,3 -diaza-spiro-[4.5]-decane derivatives, their preparation and their use in medicine, particularly in the treatment of pain.

公开(公告)号：US09688690B2

公开(公告)日：2017-06-27

申请号：US14820725

申请日：2015-08-07

Applicant: Duquesne University of the Holy Spirit

Inventor： Aleem Gangjee

IPC: C07D239/48 ,  A61K31/505 ,  C07D495/04 ,  C07D487/04 ,  A61K31/343 ,  C07D403/02 ,  C07D405/02 ,  A61K31/4709

CPC classification number: C07D495/04 ,  A61K31/343 ,  A61K31/4709 ,  A61K31/505 ,  C07D239/48 ,  C07D403/02 ,  C07D405/02 ,  C07D487/04

Abstract: The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is replaced by CH2, and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof. A method of treating a patient having cancer or a disease comprising administering to a patient an effective amount of the compound or pharmaceutically acceptable salt, hydrate, or solvate thereof.

公开(公告)号：US09682947B2

公开(公告)日：2017-06-20

申请号：US14764236

申请日：2014-01-29

Applicant: KUNMING INSTITUTE OF BOTANY, CHINESE ACADEMY OF SCIENCES ,  NEW YORK UNIVERSITY

Inventor： Chuanshu Huang ,  Qin-Shi Zhao ,  Zipeng Cao ,  Jingxia Li ,  Xu Deng ,  Chao-Ming Li

IPC: A61K31/366 ,  C07D309/38 ,  C07D311/00 ,  C07D405/02 ,  C07D407/02 ,  C07D309/32 ,  C07D491/052 ,  C07D493/04 ,  C07D513/04

CPC classification number: C07D309/32 ,  C07D491/052 ,  C07D493/04 ,  C07D513/04

Abstract: Novel heterocyclo compounds represented by Formula I wherein X, R1, R2, R3, R4, R5, R6 and n are as described herein are provided. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cancer conditions in mammals including humans, including prostate, colon, bladder, melanoma, liver, breast, cervical, ovarian, esophagi, glialblastoma, pancreatic and lung cancer.