公开(公告)号：US3891652A

公开(公告)日：1975-06-24

申请号：US37459373

申请日：1973-06-28

Applicant: SQUIBB & SONS INC

Inventor： HAUCK FREDERIC PETER ,  SUNDEEN JOSEPH E

IPC: C07D211/74 ,  C07D211/76 ,  C07D211/86 ,  C07D471/04 ,  C07D491/048 ,  C07D33/52

CPC classification number: C07D471/04 ,  C07D211/76 ,  Y10S514/821 ,  Y10S514/886

Abstract: 4-Aryl-2,3,3a,4,5,6,7,8,9,9b-decahydro-1H-pyrrolo-(3,4f)quinolines, 4-aryl-2,3,3a,4,5,7,8,9,9a,9b-decahydro-1-Hpyrrolo(3,4-f)quinolinium salts, intermediates for their preparation and methods for their preparation are disclosed. In addition, pharmaceutical compositions containing said compounds and methods for using said compositions as antiflammatory, antianginal and anti-arrhythmic agents and to reduce blood pressure are reported.

Abstract translation: 4-芳基-2,3,3a，4,5,6,7,8,9,9b-十氢-1H-吡咯并[3,4-f]喹啉，4-芳基-2,3,3a，4 ，5,7,8,9,9a，9b-十氢-1H-吡咯并[3,4-f]喹啉盐，其制备中间体及其制备方法。

公开(公告)号：US3875168A

公开(公告)日：1975-04-01

申请号：US34515473

申请日：1973-03-26

Applicant: CIBA GEIGY CORP

Inventor： PFLEIDERER WOLFGANG ,  ZONDLER HELMUT

IPC: C08K5/00 ,  C07D215/38 ,  C08G59/50 ,  C08K5/3412 ,  C07D33/52

CPC classification number: C08G59/506 ,  C07D215/38

Abstract: The new 7-amino-decahydro-quinolines are manufactured by hydroxygenating 5-amino-2-( Beta -cyanoethyl)-5-cyclohexen-1-one in a manner which is in itself known. The 5-amino-2-( Beta cyanoethyl)-5-cyclohexen-1-ones used as the starting substances can be obtained by several reactions, which are disclosed by several publications. One reaction is the cyclisation of cyanoethylated aliphatic ketones in the presence of suitable catalysts. The new 7-amino-decahydro-quinolines represent valuable curing agents for epoxide resins and advantageously 0,5 to 1,3 equivalents of nitrogen-bonded active hydrogen atoms of the 7-amino-decahydro-quinolines are used per 1 equivalent of epoxide groups of the polyepoxide compound.

Abstract translation: 新的7-氨基 - 十氢喹啉通过以本身已知的方式羟基化5-氨基-2-（β-氰基乙基）-5-环己烯-1-酮来制备。 用作起始物质的5-氨基-2-（β-氰基乙基）-5-环己烯-1-酮可以通过几个反应来获得，这些反应由几个出版物公开。 一个反应是在合适的催化剂存在下氰基乙基化脂族酮的环化。 新的7-氨基 - 十氢 - 喹啉代表环氧树脂的有价值的固化剂，并且每1当量的环氧基团优选使用0.5至1.3当量的7-氨基 - 十氢 - 喹啉的氮键合活性氢原子 的聚环氧化合物。

公开(公告)号：US3875166A

公开(公告)日：1975-04-01

申请号：US41086073

申请日：1973-10-29

Applicant: SQUIBB & SONS INC

Inventor： YALE HARRY L ,  PETIGARA RAMESH B

IPC: C07D513/04 ,  C07D33/52

CPC classification number: C07D513/04

Abstract: WHEREIN A is O or S and X, Y, R1, R2, n, n'' and n'''' are as defined hereinafter. These compounds are useful as antiinflammatory agents, and central nervous system stimulants or depressants depending on dosage.

3-(Aminoalkoxy)-2,3-dihydroquinobenzoxa(or thia) zepine derivatives are provided having the structures

Abstract translation: 提供了具有结构A为O或S且X，Y，R 1，R 2，n，n'和n“如下文所定义的3-（氨基烷氧基）-2,3-二氢喹喔啉（或硫杂） 这些化合物可用作抗炎剂，中枢神经系统兴奋剂或抑制剂，取决于剂量。

公开(公告)号：US3637677A

公开(公告)日：1972-01-25

申请号：US3637677D

申请日：1969-02-14

Applicant: US HEALTH EDUCATION & WELFARE

Inventor： BAHNER CARL T ,  BROTHERTON DAVID H ,  BROTHERTON MARY K

IPC: C07D215/12 ,  C07C87/28 ,  C07D33/52

CPC classification number: C07D215/12

Abstract: A SERIES OF NITROSOAMINES WHICH COMPRISE 4-N-NITROSON-ALKYLAMINOBENZYLIDENE DERIVATIVES OF A FUSED BICYCLIC MOIETY SELECTED FROM 1-INDENE, 2-METHYL QUINOLINE, 4-METHYL QUINOLINE, AND 1-METHYL ISOQUINOLINE. IN CONTRAST TO THE CARCINOGENIC ACTIVITY EXEMPLIFIED BY RELATED NITROSO AND AMINO COMPOUNDS, MEMBERS OF THE PRESENT GROUP OF NITROSO COMPOUNDS HAVE EXHIBITED CARCINOSTATIC ACTIVITY IN ANIMALS IN STANDARD TESTS AGAINST WALKER 256 TUMOR.

公开(公告)号：US3455932A

公开(公告)日：1969-07-15

申请号：US3455932D

申请日：1967-08-23

Applicant: SMITHKLINE CORP

Inventor： LOEV BERNARD

IPC: C07D215/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/38 ,  C07D215/48 ,  C07D221/16 ,  C07D33/52 ,  A61K27/00

CPC classification number: C07D215/227 ,  C07D215/18 ,  C07D215/38 ,  C07D215/48 ,  C07D221/16

公开(公告)号：US3830816A

公开(公告)日：1974-08-20

申请号：US23853072

申请日：1972-03-27

Applicant: ASPRO NICHOLAS LTD

Inventor： GITTOS M ,  JAMES J ,  VERGE J

IPC: C07D217/22 ,  C07D223/16 ,  C07D471/04 ,  C07D33/52

CPC classification number: C07D223/16 ,  C07D217/22 ,  C07D471/04

Abstract: 1-CYCLOPRPOYLMETHYLENEAMINO-3,4- DIHYDROISQUINOLINE IS A NOVEL COMPOUND POSSESSING HYPOTENSIVE ACTIVITY. IT MAY BE PREPARED BY THE REACTION OF CYCLOPROPYLMETHYLENE AMINO WITH 1,2,3,4-TETRAHYDRO-1-ISOQUINOLTHIONE OR WITH 1-ALKYLTHIO-3,4-DIHYDROISOQUINOLINE.

公开(公告)号：US3730956A

公开(公告)日：1973-05-01

申请号：US3730956D

申请日：1971-11-26

Applicant: LILLY CO ELI

Inventor： GERZON K

IPC: C07D215/42 ,  C07D33/52

CPC classification number: C07D215/42 ,  Y10S514/895

Abstract: A group of novel 4-(adamantylamino)quinoline compounds which are useful as algaecides and protozoacides. Some are useful as anti malarias.

Abstract translation: 一组新颖的4-（金刚烷基氨基）喹啉化合物，可用作除藻剂和原生动物。 有些是有用的反疟疾。

公开(公告)号：US3668207A

公开(公告)日：1972-06-06

申请号：US3668207D

申请日：1970-01-22

Applicant: CIBA GEIGY CORP

Inventor： CARNEY RICHARD WILLIAM JAMES

IPC: C07D401/12 ,  C07D33/52

CPC classification number: C07D401/12

Abstract: 2-Amino-4-aryl-quinolines, e.g. those of the formula

ACYL DERIVATIVES, QUATERNARIES AND SALTS THEREOF, EXHIBIT ANTIINFLAMMATORY EFFECTS.

Abstract translation: 2-氨基-4-芳基 - 喹啉，例如 式ACYL衍生物，季铵盐及其盐类，展示抗炎药效果。

公开(公告)号：US3624088A

公开(公告)日：1971-11-30

申请号：US3624088D

申请日：1969-04-10

Applicant: EGYT GYOGYSZERVEGYESZETI GYAR

Inventor： BENKO PAL ,  BUDAI ZOLTAN ,  PALLOS LASZLO ,  BERENYI EDIT

IPC: A61K31/425 ,  A61K31/47 ,  C07D215/40 ,  C07D215/42 ,  C07D277/42 ,  C07D277/58 ,  C07D33/52

CPC classification number: A61K31/425 ,  A61K31/47 ,  C07D215/40 ,  C07D215/42 ,  C07D277/42 ,  C07D277/58

Abstract: Trichloro ethylidine amine derivatives of quinolines, thiazoles and tetrahydronaphthalenes having anthelmonthic and fungicidal activity are disclosed.

公开(公告)号：US3502682A

公开(公告)日：1970-03-24

申请号：US3502682D

申请日：1969-05-15

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS ANDRE ,  GIRAULT PIERRE ,  JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: A61K31/00 ,  A61K31/395 ,  C07D215/44 ,  C07D33/52

CPC classification number: A61K31/00 ,  A61K31/395 ,  C07D215/44