公开(公告)号：US06388087B1

公开(公告)日：2002-05-14

申请号：US09718947

申请日：2000-11-21

Applicant: Abdollah Bashir-Hashemi ,  Kurt Baum

Inventor： Abdollah Bashir-Hashemi ,  Kurt Baum

IPC: C07D27108

CPC classification number: C06B25/34 ,  C07D271/08

Abstract: The novel compound 3,3-Dinitro-4,4′-hydrozofurazan and the methods of preparation. The method of preparation 3,3-Dinitro-4,4′-hydrazofurazan which comprises partially reducing 3,3′-Dinitro-4,4′-azoxyfurazan. The method of preparing 3,3′-Dinitro-4,4′-hydrazofurazan by the partial reduction of 3,3′-Dinitro-4,4′-azofurazan.

Abstract translation: 新型化合物3,3,3-二硝基-4,​​4'-氢唑唑烷及其制备方法。 制备3,3,3-二硝基-4,​​4'-咔唑的方法，该方法包括部分还原3,3'-二硝基-4,​​4'-氮杂氧杂呋喃。 通过部分还原3,3'-二硝基-4,​​4'-唑烷来制备3,3'-二硝基-4,​​4'-咔唑的方法。

公开(公告)号：US06552201B2

公开(公告)日：2003-04-22

申请号：US10020329

申请日：2001-10-30

Applicant: Michael A. Hiskey ,  David E. Chavez ,  Robert L. Bishop ,  John F. Kramer ,  Scott A. Kinkead

Inventor： Michael A. Hiskey ,  David E. Chavez ,  Robert L. Bishop ,  John F. Kramer ,  Scott A. Kinkead

IPC: C07D27108

CPC classification number: C06B43/00 ,  C06B25/04 ,  C07D271/08

Abstract: A method of preparing 3,3′-diamino-4,4′-azofurazan is provided together with a composition of matter including a mixture of 3,3′-diamino-4,4′-azofurazan and 1,3,5-triamino-2,4,6-trinitrobenzene.

Abstract translation: 一种制备3,3'-二氨基-4,4'-氮呋哇烷的方法与一种包含3,3'-二氨基-4,4'-唑烷和1,3,5-三氨基的混合物的组合物一起提供 -2,4,6-三硝基苯。

公开(公告)号：US06384215B1

公开(公告)日：2002-05-07

申请号：US09875043

申请日：2001-06-07

Applicant: Pandurang Balwant Deshpande ,  Parven Kumar Luthra

Inventor： Pandurang Balwant Deshpande ,  Parven Kumar Luthra

IPC: C07D27108

CPC classification number: C07D271/113 ,  C07D501/00

Abstract: The present invention provides new thioester derivatives of 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (I), also, the invention provides a method by which the said thioester derivatives can be prepared by reacting 4-halogeno-2-methoxyimino-3-oxo-butyric acid of the general formula (II) with 2-mercapto-5-substituted-1,3,4-oxadiazoles of the general formula (III) in a solvent, in the presence of DMF/POCl3 and in presence of an organic base and if desired the so obtained thioester derivatives so obtained are reacted with 7-amino-cephem carboxylic acids of the general formula (V) to produce condensed products which are insitu reacted with thiourea to get cephalosporin antibiotic compounds having the general formula (VI).

Abstract translation: 本发明提供了通式（I）的4-卤代-2-甲氧基亚氨基-3-氧代 - 丁酸的新的硫代酯衍生物，本发明还提供了一种可通过使4- 通式（II）的2-氧代-2-甲氧基亚氨基-3-氧代 - 丁酸与通式（III）的2-巯基-5-取代-1,3,4-恶二唑在溶剂中，在 DMF / POCl 3并在有机碱的存在下，如果需要，如此得到的硫酯类衍生物与通式（Ⅴ）的7-氨基头孢烯羧酸反应，生成与硫脲本身反应得到头孢菌素的缩合产物 具有通式（VI）的抗生素化合物。