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    Process for producing vinyl ether compounds
    1.
    发明申请
    Process for producing vinyl ether compounds 失效
    制备乙烯基醚化合物的方法

    公开(公告)号：US20030083529A1

    公开(公告)日：2003-05-01

    申请号：US10231115

    申请日：2002-08-30

    发明人： Yasutaka Ishii ,  Tatsuya Nakano ,  Keizo Inoue

    IPC分类号： C07C041/16

    CPC分类号： C07D313/10 ,  C07C41/16 ,  C07C43/162 ,  C07C49/753 ,  C07C69/757 ,  C07C2601/14 ,  C07C2603/74 ,  C07C2603/86 ,  C07D307/33 ,  C07D307/93 ,  Y02P20/55 ,  C07C43/16 ,  C07C43/168 ,  C07C43/178 ,  C07C43/188 ,  C07C43/215

    摘要： A process produces vinyl ether compounds and includes allowing a vinyl ester compound represented by following Formula (1): 1 wherein R1, R2, R3 and R4 are the same or different and are each a hydrogen atom or an organic group, to react with a hydroxy compound represented by following Formula (2):R5OHnullnull(2)wherein R5 is an organic group, in the presence of at least one transition element compound to thereby yield a vinyl ether compound represented by following Formula (3): 2 wherein R2, R3, R4 and R5 have the same meanings as defined above. Such transition element compounds include iridium compounds and other compounds containing Group VIII elements.

    摘要翻译： 一种方法制备乙烯基醚化合物，包括使下式（1）表示的乙烯基酯化合物：其中R 1，R 2，R 3和R 4相同或不同，各自为氢原子或有机基团，与羟基 由下式（2）表示的化合物：R5OH（2）其中R5是有机基团，在至少一种过渡元素化合物的存在下，由此得到由下式（3）表示的乙烯基醚化合物：其中R2，R3， R4和R5具有与上述相同的含义。 这种过渡元素化合物包括铱化合物和含有VIII族元素的其它化合物。

    Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
    3.
    发明申请
    Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols 有权

    公开(公告)号：US20030216583A1

    公开(公告)日：2003-11-20

    申请号：US10459763

    申请日：2003-06-12

    发明人： Wen-Chung Shieh ,  Steven Dell

    IPC分类号： C07D235/18 ,  C07D209/82 ,  C07D209/04 ,  C07C041/16

    CPC分类号： C07D235/06 ,  C07C41/16 ,  C07D209/08 ,  C07D209/86 ,  C07D235/18 ,  C07C43/2055 ,  C07C43/205

    摘要： An accelerated process for preparing an O-methyl phenol comprising reacting a phenol with dimethyl carbonate in the presence of a catalyst selected from 1,8-diazabicyclonull5.4.0nullundec-7-ene; 1,4-diazabicyclonull2.2.2nulloctane; and dimethylaminopyridine. According to another aspect, the invention provides an accelerated process for preparing an N-methyl heteroaromatic compound comprising reacting an NH-containing heteroaromatic compound with dimethyl carbonate in the presence of a catalyst selected from 1,8-diazabicyclonull5.4.0nullundec-7-ene; 1,4-diazabicyclonull2.2.2nulloctane; and dimethylaminopyridine. According to an additional aspect, the invention provides an accelerated process for preparing a methylated aminophenol comprising reacting an aminophenol having at least one NnullH with dimethyl carbonate in the presence of a catalyst selected from 1,8-diazabicyclonull5.4.0nullundec-7-ene; 1,4-diazabicyclonull2.2.2nulloctane; and dimethylaminopyridine. The process of the invention is especially advantageous since the process: (1) utilizes an environmentally friendly methylating reagent, dimethylcarbonate; (2) produces a high yield of the O-methyl phenols, N-methyl aromatic amines, and/or methylated aminophenols, generally 97-100% conversion; and (3) does not require a high-pressure (autoclave) reactor.

    Hexameric complexes and their preparation
    4.
    发明申请
    Hexameric complexes and their preparation 失效
    六聚体配合物及其制备方法

    公开(公告)号：US20030073872A1

    公开(公告)日：2003-04-17

    申请号：US09978925

    申请日：2001-10-16

    发明人： Jerry L. Atwood

    IPC分类号： C07C041/16

    CPC分类号： C07C39/15 ,  Y10S977/84

    摘要： A composition comprising a guest/host assembly having a spheroidal host assembly comprised of a hexamer of a methylene-bridged trihydroxybenzene tetramer and a guest component encapsulated within the spheroidal host assembly to provide a highly stable guest/host assembly. A guest component, specifically a pharmaceutically active agent, is encapsulated within the spheroidal host assembly to provide a guest/host assembly exhibiting a high stability, being stable upon a solubilization in a mixture of acetone and water in a one-to-one ratio for a period of one day at a temperature of 37null C. The pharmaceutically active agent encapsulated within the spheroidal hexamer is selected from the group consisting of Depakote, Wellbutrin, Allegra, Neurontin, Zovirax, and Claritin. A process for the preparation of a hexameric complex, as described above, from a methylene-bridged tetramer solubilized in an amphiphilic organic solvent. An activator is incorporated into the amphiphilic solvent containing the tetramer. The activator comprises an organic compound of a lower molecular weight than that of the tetramer which is functionalized with at least one of an acidic group, a halogen, an amino group, an amido group, an ester group, or an hydroxy group. The tetramer may be prepared from an aldehyde and pyrogallol which are reacted under conditions to produce a condensation product of the methylene-bridged cyclic tetramer.

    摘要翻译： 包含客体/主体组合物的组合物，其具有由亚甲基桥接的三羟基苯四聚体的六聚体组成的球形主体组合物和封装在球状主体组件内的客体组分以提供高度稳定的客体/主机组件。 客体组分，特别是药物活性剂被包封在球形宿主组件内，以提供呈现高稳定性的客体/主体组合物，其在丙酮和水的混合物中以一比一的比例溶解时是稳定的 在37℃的温度下一天的时间。包封在球形六聚体内的药物活性剂选自Depakote，Wellbutrin，Allegra，Neurontin，Zovirax和Claritin。 如上所述，从溶解在两亲性有机溶剂中的亚甲基桥连四聚体制备六聚体络合物的方法。 将活化剂掺入含有四聚体的两亲溶剂中。 所述活化剂包括比用酸性基团，卤素，氨基，酰胺基，酯基或羟基中的至少一个官能化的四聚物的分子量低的有机化合物。 四聚体可以由醛和连苯三酚制备，其在条件下反应以产生亚甲基桥连的环状四聚体的缩合产物。

    Process for the synthesis of aryl alkyl monoethers
    5.
    发明申请
    Process for the synthesis of aryl alkyl monoethers 失效
    芳基烷基单醚的合成方法

    公开(公告)号：US20020193641A1

    公开(公告)日：2002-12-19

    申请号：US10079460

    申请日：2002-02-20

    发明人： Elisabeth Borredon ,  Antoine Gaset ,  Samedy Ouk ,  Sophie Thiebaud-Roux ,  Pierre Le Gars

    IPC分类号： C07C041/16

    CPC分类号： C07C41/16 ,  C07C45/71 ,  C07C49/84 ,  C07C43/205 ,  C07C43/202 ,  C07C43/225 ,  C07C43/23

    摘要： The invention relates to a process for the synthesis of aryl alkyl monoethers by reaction of a phenol compound, comprising one or more hydroxyl groups attached to the aromatic system, and of a dialkyl carbonate. It is a solvent-free process carried out at a pressure of between 0.93null105 Pa and 1.07null105 Pa, at a temperature of between 100null C. and 200null C., and in the presence of a catalyst chosen from the group consisting of alkaline carbonates and alkaline hydroxides. The dialkyl carbonate is added gradually to the reaction mixture.

    摘要翻译： 本发明涉及通过包含一个或多个与芳族体系连接的羟基的酚化合物和碳酸二烷基酯的反应合成芳基烷基单醚的方法。 在0.93×10 5 Pa至1.07×10 5 Pa之间的压力下，在100℃至200℃之间的温度下进行无溶剂处理，并且在选自以下的催化剂存在下进行： 碱性碳酸盐和碱性氢氧化物。 将碳酸二烷基酯逐渐加入到反应混合物中。