公开(公告)号：US06630461B2

公开(公告)日：2003-10-07

申请号：US09882264

申请日：2001-06-15

Applicant: Pierre Etienne Chabrier de Lassauniere ,  Serge Auvin ,  Dennis Bigg ,  Michel Auguet ,  Jeremiah Harnett

Inventor： Pierre Etienne Chabrier de Lassauniere ,  Serge Auvin ,  Dennis Bigg ,  Michel Auguet ,  Jeremiah Harnett

IPC: A61K31395

CPC classification number: C07D417/12 ,  C07D333/38 ,  C07D409/12

Abstract: A method for treating neurodegenerative diseases in a warm-blooded animal comprising administering to a warm-blooded animal in need thereof an amount of a compound of the formula wherein A selected from the group consisting of hydrogen and wherein the substituents are defined as set forth in the specification.

Abstract translation: 一种用于治疗温血动物中的神经退行性疾病的方法，其包括向有需要的温血动物施用一定数量的选自氢并且其中所述取代基的选择性化合物的化合物定义如说明书 。

公开(公告)号：US06369050B1

公开(公告)日：2002-04-09

申请号：US09647925

申请日：2000-11-17

Applicant: Yoshimi Matsumoto ,  Shuichi Tawara ,  Hitoshi Nishio ,  Takashi Harimoto ,  Ryoji Sekiyama

Inventor： Yoshimi Matsumoto ,  Shuichi Tawara ,  Hitoshi Nishio ,  Takashi Harimoto ,  Ryoji Sekiyama

IPC: A61K31395

CPC classification number: A61K31/546 ,  A61K31/43 ,  A61K31/545 ,  A61K2300/00

Abstract: The invention provides an antimicrobial agent capable of producing an excellent effect in the prevention or treatment of bacteria of two or more genera selected from among Streptococcus, Moraxella, Haemophilus, Klebsiella and the like. The agent comprises a penicillin antibiotic, in particular amoxicillin, and a cephem antibiotic, in particular cefixime or cefdinir. The antimicrobial agent of the invention is administered in the form of a mixed preparation containing both or in the form of individual preparations respectively containing them for combined administration.

Abstract translation: 本发明提供能够在预防或治疗选自链球菌属，莫拉氏菌属，嗜血杆菌属，克雷伯菌属等中的两种以上的细菌方面产生优异效果的抗微生物剂。 该试剂包括青霉素抗生素，特别是阿莫西林，和头孢类抗生素，特别是头孢克肟或头孢地尼。 本发明的抗微生物剂以混合制剂的形式给药，所述混合制剂含有分别含有它们用于联合给药的单独制剂或以其形式存在。

公开(公告)号：US06172069B2

公开(公告)日：2001-01-09

申请号：US08936572

申请日：1997-09-24

Applicant: Paul Dale Klimstra ,  Barbara Roniker ,  Edward Allen Swabb

Inventor： Paul Dale Klimstra ,  Barbara Roniker ,  Edward Allen Swabb

IPC: A61K31395

CPC classification number: A61K31/65 ,  A61K31/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505

Abstract: The present invention provides a method for preventing or reducing a photosensitivity and/or phototoxicity reaction which may be caused by a once-per-day dose of a medication which causes a photosensitivity and/or phototoxicity reaction in a patient comprising administering the prescribed or suggested dose of the medication to the patient during the evening or early morning hours. The present invention also provides an article of manufacture comprising: (1) a packaging material, and (2) a once-a-day dose medication which causes a photosensitivity and/or a phototoxicity reaction in a patient contained within said packaging material, wherein such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and wherein said packaging material comprises a label which indicates that such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and/or that such medication is to be administered during the evening or early morning hours, and/or wherein the packaging material is arranged in a manner which releases the medication to the patient during the evening or early morning hours.

Abstract translation: 本发明提供了一种用于预防或减少可能由每天一次的药物剂量引起的光敏性和/或光毒性反应的方法，其导致患者的光敏性和/或光毒性反应，包括施用规定的或建议的 本发明还提供了一种制品，其包括：（1）包装材料，和（2）一天一次的剂量药物，其引起光敏性和 或者在所述包装材料中包含的患者中的光毒性反应，其中通过在傍晚或清晨时间向患者施用药物来防止或减少这种反应，并且其中所述包装材料包括标签，其指示这样的 通过在傍晚或清晨时间向患者施用药物来防止或减少反应，和/或这样的m 在傍晚或清晨时间期间施用鞣制，和/或其中包装材料以在傍晚或清晨时间向患者释放药物的方式排列。

公开(公告)号：US06835727B2

公开(公告)日：2004-12-28

申请号：US10204772

申请日：2002-08-23

Applicant: Osamu Okamoto ,  Jean-Pierre Falgueyret ,  Renata Marcella Oballa ,  Petpiboon Prasit ,  Robert Rydzewski

Inventor： Osamu Okamoto ,  Jean-Pierre Falgueyret ,  Renata Marcella Oballa ,  Petpiboon Prasit ,  Robert Rydzewski

IPC: A61K31395

CPC classification number: C07D207/08 ,  C07D205/04 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/277 ,  C07D209/62 ,  C07D471/04

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of Cathepsins K and L. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract translation: 本发明涉及一类新的半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K和L的抑制剂。这些化合物可用于治疗其中指出骨吸收抑制的疾病，例如骨质疏松症。

公开(公告)号：US06593297B2

公开(公告)日：2003-07-15

申请号：US09264516

申请日：1999-03-08

Applicant: Orest W. Blaschuk ,  James Matthew Symonds ,  Stephen Byers ,  Barbara J. Gour

Inventor： Orest W. Blaschuk ,  James Matthew Symonds ,  Stephen Byers ,  Barbara J. Gour

IPC: A61K31395

CPC classification number: C07K14/705 ,  A61K38/00 ,  Y10S977/91 ,  Y10S977/915

Abstract: Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-peptide mimetic of an OB-cadherin CAR sequence; (c) a substance, such as an antibody or antigen-binding fragment thereof, that specifically binds an OB-cadherin CAR sequence; and/or (d) a polynucleotide encoding a polypeptide that comprises an OB-cadherin CAR sequence or analogue thereof.

公开(公告)号：US06589934B1

公开(公告)日：2003-07-08

申请号：US09581386

申请日：2000-06-13

Applicant: Dulce Garrido Bubacz ,  Iain David Dukes ,  Ed Williams McLean ,  Robert Anderson Noe ,  Andrew James Peat ,  Jerzy Ryszard Szewczyk ,  Stephen Andrew Thomson ,  Jennings Franklin Worley, III

Inventor： Dulce Garrido Bubacz ,  Iain David Dukes ,  Ed Williams McLean ,  Robert Anderson Noe ,  Andrew James Peat ,  Jerzy Ryszard Szewczyk ,  Stephen Andrew Thomson ,  Jennings Franklin Worley, III

IPC: A61K31395

CPC classification number: G01N33/6872 ,  C07D471/08 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/507 ,  G01N33/5088 ,  G01N2333/705

Abstract: The invention relates to methods of treatment of non insulin dependent diabetes mellitus, antagonists of the delayed rectifier potassium channel Kv2.1, methods of using and preparing the antagonists and assays for identifying such antagonists.

Abstract translation: 本发明涉及治疗非胰岛素依赖性糖尿病的方法，延迟整流钾通道Kv2.1的拮抗剂，使用和制备拮抗剂的方法以及用于鉴定此类拮抗剂的测定法。

公开(公告)号：US06492355B1

公开(公告)日：2002-12-10

申请号：US09555489

申请日：2000-06-01

Applicant: Lilian Alcaraz ,  Mark Furber ,  Michael P. Mortimore

Inventor： Lilian Alcaraz ,  Mark Furber ,  Michael P. Mortimore

IPC: A61K31395

CPC classification number: C07D295/192 ,  C07C235/46 ,  C07C237/30 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/74 ,  C07D207/12 ,  C07D207/14 ,  C07D211/42 ,  C07D211/46 ,  C07D211/58 ,  C07D295/088 ,  C07D295/155

Abstract: The invention provides compounds of general formula in which m, A, R1 and Ar have the meanings defined in the specification; a process for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.

Abstract translation: 本发明提供了m，A，R 1和Ar具有本说明书中定义的含义的通式化合物。 其准备过程; 含有它们的药物组合物; 制备药物组合物的方法; 及其在治疗中的应用。

公开(公告)号：US06716834B2

公开(公告)日：2004-04-06

申请号：US10276150

申请日：2002-11-12

Applicant: Kjell Andersson ,  Tord Inghardt ,  Olle Karlsson ,  Marcel Linschoten ,  Jan-Erik Nyström ,  Gunnel Sundén

Inventor： Kjell Andersson ,  Tord Inghardt ,  Olle Karlsson ,  Marcel Linschoten ,  Jan-Erik Nyström ,  Gunnel Sundén

IPC: A61K31395

CPC classification number: C07D409/06 ,  C07D413/14

Abstract: There is provided compounds of formulae I and IA wherein Y, R1, R2, R3, D1 and D2 have meanings given in the description which are useful as, or as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

Abstract translation: 提供式I和IA的化合物，其中Y，R 1，R 2，R 3，D 1和D 2具有在本说明书中给出的含义，或作为 ，胰蛋白酶样蛋白酶如凝血酶的竞争性抑制剂，特别是在需要抑制凝血酶（例如血栓形成）或作为抗凝剂的条件的治疗中。

公开(公告)号：US06583280B1

公开(公告)日：2003-06-24

申请号：US09864868

申请日：2001-05-25

Applicant: Nada H. Saab-Ishmail

Inventor： Nada H. Saab-Ishmail

IPC: A61K31395

CPC classification number: C07D245/02

Abstract: Novel compounds are chiral compounds which are conformationally restricted polyamine analogues for use in imaging and for therapeutic use in treatment of tumors. These analogues diminish the ability to aggregate DNA seen in the parent polyamines. The invention provides for synthesis of a library of analogues with fine structural modifications which retain restriction and conservation of the molecular weight of the parent polyamines.

Abstract translation: 新型化合物是用于成像和用于治疗肿瘤的治疗用途的构象限制性多胺类似物的手性化合物。 这些类似物降低了在母体多胺中聚集DNA的能力。 本发明提供了具有精细结构修饰的类似物文库的合成，其保留了母体多胺的分子量的限制和保守性。

公开(公告)号：US06426341B1

公开(公告)日：2002-07-30

申请号：US09602793

申请日：2000-06-23

Applicant: Banavara L. Mylari

Inventor： Banavara L. Mylari

IPC: A61K31395

CPC classification number: A61K31/498 ,  A61K45/06 ,  Y10S514/866 ,  A61K2300/00

Abstract: This invention is directed to methods, pharmaceutical compositions and kits comprising an aldose reductase inhibitor (ARI), a prodrug thereof or a pharmaceutically acceptable salt of said ARI or said prodrug and a selective COX-2 inhibitor, a prodrug thereof or a pharmaceutically acceptable salt of said selective COX-2 inhibitor or said prodrug. This invention further relates to methods of using those pharmaceutical compositions for the treatment of diabetic complications such as diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, myocardial infarction, cataracts and diabetic cardiomyopathy.

Abstract translation: 本发明涉及包含醛糖还原酶抑制剂（ARI），其前药或所述ARI或所述前药的药学上可接受的盐和选择性COX-2抑制剂，其前药或药学上可接受的盐的方法，药物组合物和试剂盒 的所述选择性COX-2抑制剂或所述前药。 本发明还涉及使用这些药物组合物来治疗糖尿病性并发症如糖尿病性神经病，糖尿病性肾病，糖尿病性视网膜病变，心肌梗死，白内障和糖尿病性心肌病的方法。