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公开(公告)号：US07135493B2
公开(公告)日：2006-11-14
申请号：US10754541
申请日：2004-01-12
IPC分类号： A61K31/4188 , A61K31/484 , A61K31/4164 , C07D233/61 , C07D491/113 , C07D487/04 , C07D235/08
CPC分类号： C07D213/75 , C07C57/58 , C07C61/40 , C07C211/50 , C07C211/52 , C07C233/22 , C07C233/31 , C07C233/43 , C07C233/44 , C07C233/51 , C07C271/28 , C07D233/56 , C07D233/64 , C07D233/68 , C07D233/70 , C07D233/90 , C07D235/12 , C07D235/16 , C07D239/47 , C07D317/66 , C07D401/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D471/04 , C07D473/08 , C07D491/04
摘要： A compound having the following formula (I): wherein R1 is N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), R2 is hydroxyamino, R3 is hydrogen or a suitable substituent, L1 is —(CH2)n— (wherein n is an integer of 0 to 6) optionally substituted with one or more suitable substituent(s), wherein one or more methylene(s) may be replaced with suitable heteroatom(s), and L2 is lower alkenylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.
摘要翻译： 具有下式（I）的化合物：其中R 1是任选被一个或多个合适的取代基取代的含N的杂环，R 2是羟基氨基， R 3是氢或合适的取代基，L 1是 - （CH 2 CH 2）n - （其中n 是0至6的整数），其任选地被一个或多个合适的取代基取代，其中一个或多个亚甲基可被适当的杂原子替代，并且L 2低 亚烯基或其盐。 该化合物可用作组蛋白脱乙酰酶抑制剂。
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公开(公告)号：US07105546B2
公开(公告)日：2006-09-12
申请号：US10060662
申请日：2002-01-30
申请人： Michael Mullican , David Lauffer , Roger Tung
发明人： Michael Mullican , David Lauffer , Roger Tung
IPC分类号： A61K31/4409 , A61K31/484 , C07D403/06
CPC分类号： C07D401/06 , C07D207/06 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04
摘要： The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
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