公开(公告)号：US06197826B1

公开(公告)日：2001-03-06

申请号：US09354577

申请日：1999-07-16

Applicant: L. David Waterbury ,  John M. Carney ,  Allan L. Wilcox

Inventor： L. David Waterbury ,  John M. Carney ,  Allan L. Wilcox

IPC: A01N3324

CPC classification number: C07C291/02

Abstract: Disclosed are novel &agr;-(2-hydroxyphenyl) nitrone compounds and pharmaceutical compositions containing such compounds. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.

Abstract translation: 公开了新的α-（2-羟基苯基）硝酮化合物和含有这些化合物的药物组合物。 所公开的组合物可用作哺乳动物例如关节炎中的炎症相关病症的治疗剂，以及用作检测自由基的分析试剂。

公开(公告)号：US06268309B1

公开(公告)日：2001-07-31

申请号：US09460310

申请日：1999-12-13

Applicant: Péter Literáti Nagy ,  Miklós Kálmán

Inventor： Péter Literáti Nagy ,  Miklós Kálmán

IPC: A01N3324

CPC classification number: A01N43/40 ,  A01N37/28 ,  A01N37/52 ,  A01N43/88

Abstract: Compositions containing hydroximic acid derivatives of the formula where R1, R2, R3, R, X, Y, A, and B are as defined in the specification, are useful for the promotion of plant production and/or for the elimination of unfavourable environmental influences in plant cultivation.

Abstract translation: 含有式R 1，R 2，R 3，R，X，Y，A和B的含氢阿魏酸衍生物的组合物如本说明书中所定义，可用于促进植物生产和/或消除不利的环境影响 植物栽培。

公开(公告)号：US06255352B1

公开(公告)日：2001-07-03

申请号：US09423860

申请日：1999-11-17

Applicant: Wassilios Grammenos ,  Ruth Müller ,  Hubert Sauter ,  Herbert Bayer ,  Thomas Grote ,  Andreas Gypser ,  Reinhard Kirstgen ,  Bernd Müller ,  Arne Ptock ,  Franz Röhl ,  Gisela Lorenz ,  Eberhard Ammermann ,  Siegfried Strathmann

Inventor： Wassilios Grammenos ,  Ruth Müller ,  Hubert Sauter ,  Herbert Bayer ,  Thomas Grote ,  Andreas Gypser ,  Reinhard Kirstgen ,  Bernd Müller ,  Arne Ptock ,  Franz Röhl ,  Gisela Lorenz ,  Eberhard Ammermann ,  Siegfried Strathmann

IPC: A01N3324

CPC classification number: A01N35/10

Abstract: A method for control of harmful fungi is provided by treating the fungi, or the materials, plants, the soil or seeds to be protected against fungal infection, with an effective amount of a bisoxime of the formula I or a salt or adduct thereof, the index and the substituents having the following meanings: R1 is halogen, alkyl or haloalkyl; R2 is cyano, nitro, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylamino, dialkylamino, alkylaminocarbonyl, substituted or unsubstituted phenyl, phenoxy or phenylthio; n is 0, 1, 2 or 3; R3 is alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl or phenylalkyl.

Abstract translation: 通过用有效量的式I的二肟或其盐或其加合物处理真菌或材料，植物，待保护的土壤或种子免受真菌感染，提供有害真菌的控制方法，指数 并且具有以下含义的取代基：R 1是卤素，烷基或卤代烷基; R 2是氰基，硝基，卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，烷硫基，烷基氨基，二烷基氨基，烷基氨基羰基，取代或未取代的苯基，苯氧基或苯硫基; n 为0,1,2或3; R3为烷基，卤代烷基，烯基，卤代烯基，炔基，卤代炔基或苯基烷基。

公开(公告)号：US06589995B2

公开(公告)日：2003-07-08

申请号：US09813534

申请日：2001-03-21

Applicant: Robert Konrad ,  Jeffrey Kudlow

Inventor： Robert Konrad ,  Jeffrey Kudlow

IPC: A01N3324

CPC classification number: A61K31/655

Abstract: The present invention demonstrates a method for inhibiting O-linked protein glycosylation in a tissue or cell, comprising the step of contacting said tissue or cell with (Z)-1-[N-(3-Ammoniopropyl)-N-(n-propyl)amino] diazen-ium-1,2-diolate or a derivative thereof. The present invention is also directed to a method of treating or inhibiting the onset of diabetes mellitis in an individual in need of such treatment, comprising the step of admininstering to said individual a pharmacological dose of a compound which inhibiting O-linked protein glycosylation in a tissue or cell of said individual. Further, the present invention provides a pharmaceutical composition, comprising (Z)-1-[N-(3-Ammoniopropyl)-N-(n-propyl)amino] diazen-ium-1,2-diolate and a pharmaceutically acceptable carrier or a derivative thereof.

Abstract translation: 本发明揭示了一种抑制组织或细胞中O-连锁蛋白糖基化的方法，包括使所述组织或细胞与（Z）-1- [N-（3-氨基丙基）-N-（正丙基） ）氨基]二氮烯-1,2-二醇酯或其衍生物。 本发明还涉及在需要这种治疗的个体中治疗或抑制糖尿病发病的方法，其包括以下步骤：向所述个体施用在一种或多种药物中抑制O-连接蛋白糖基化的化合物的药理学剂量 所述个体的组织或细胞。 此外，本发明提供了一种药物组合物，其包含（Z）-1- [N-（3-氨基丙基）-N-（正丙基）氨基]二氮烯-1,2-二醇酯和药学上可接受的载体或 其衍生物。

公开(公告)号：US06433010B1

公开(公告)日：2002-08-13

申请号：US09822479

申请日：2001-04-02

Applicant: Jan Glinski ,  Keith L. Branly

Inventor： Jan Glinski ,  Keith L. Branly

IPC: A01N3324

Abstract: The present invention relates to fungicidally effective compositions containing at least one pentacyclic triterpene compound.

公开(公告)号：US06288071B1

公开(公告)日：2001-09-11

申请号：US09202264

申请日：1998-12-10

Applicant: Henry Szczepanski ,  Martin Zeller ,  Ottmar Franz Hüter

Inventor： Henry Szczepanski ,  Martin Zeller ,  Ottmar Franz Hüter

IPC: A01N3324

CPC classification number: C07D213/53 ,  A01N37/36 ,  A01N37/42 ,  A01N37/50 ,  A01N43/40 ,  A01N43/50 ,  A01N43/80 ,  C07C251/60 ,  C07C2601/16 ,  C07D211/76 ,  C07D233/86 ,  C07D261/08 ,  C07D295/155

Abstract: Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in plant protection.

Abstract translation: 要求保护作为酯，肟或酰胺的式I的农药活性环己二烯基衍生物化合物。 这些化合物可用作植物保护中的杀真菌剂，杀螨剂和杀虫剂。