摘要:
The invention relates to carbamates having general structure (I), wherein: R1, R2 and R3 are H, OH, SH, CN, F, Cl, Br, I, (C1–C4)-alkylthio, (C1–C4)-alkoxyl, (C1–C4)-alkoxyl substituted by one or several F radicals, carbamoylamine, (C1–C4)alkyl and (C1–C4)alkyl substituted by one or several F or OH radicals; R4 represents a substituted or non-substituted cycloalkyl or cycloaryl radical (a heteroalkyl radical or not). The amine of the quinuclidine ring can also be forming quaternary ammonium salts or in an oxidized state (N-oxide). Carbamates (I) are antagonists of the M3 muscarinic receptor, and selectively, the M2 receptor. Hence, they can be used in the treatment of urinary incontinence (particularly due to bladder instability), irritable bowel syndrome, diseases of the respiratory tract (particularly chronic obstructive pulmonary disease, chronic bronchitis, asthma, emphysema and rhinitis) and in ophthalmologic operations.
摘要:
Method and apparatus for feeding original and copy sheets in a duplicator having an improved copyboard containing a radiation-transmissive plate adapted to carry superposed thereon the original and copy sheets with the original disposed between the plate and the copy sheet, the copyboard being linearly reciprocatable between a loading station, at which the original and copy sheets may be positioned on the plate, and an exposure station, at which the copy sheet is exposed through the radiation-transmissive plate and the original sheet and is thereafter removed for further processing. At the end of each exposure cycle, the copyboard moves back to the loading station carrying thereon the original sheet for the initiation of a subsequent sequence. Also disclosed are method and apparatus for accurately registering the copy sheet and original sheet on the copyboard and method and apparatus for separating the exposed copy sheet from the original sheet.
摘要:
Method and apparatus for feeding original and copy sheets in a duplicator having an improved copyboard containing a radiationtransmissive plate adapted to carry superposed thereon the original and copy sheets with the original disposed between the plate and the copy sheet, the copyboard being linearly reciprocatable between a loading station, at which the original and copy sheets may be positioned on the plate, and an exposure station, at which the copy sheet is exposed through the radiation-transmissive plate and the original sheet and is thereafter removed for further processing. At the end of each exposure cycle, the copyboard moves back to the loading station carrying thereon the original sheet for the initiation of a subsequent sequence. Also disclosed are method and apparatus for accurately registering the copy sheet and original sheet on the copyboard and method and apparatus for separating the exposed copy sheet from the original sheet.
摘要:
A method and apparatus for continuous contact printing from a moving master strip onto a moving duplicate strip of lightsensitive material. A vacuum is applied to the inner or facing surfaces of the master and duplicate strips to keep them in register with each other by withdrawing air from the space between them. Air is so withdrawn either in an entrance region before the longitudinally moving strips come into close proximity with each other, or in an exit region beyond which the moving strips begin to diverge from each other. At least some of the air that is withdrawn from the space between the strips is caused to leave that space along a path generally parallel to the direction of strip movement. The vacuum may be applied through a perforated wedge which guides the strips into close proximity with each other.
摘要:
An original document if fed rearwardly into an inlet slot near the top of a copying machine, where it is lapped with a printing paper sheet fed toward the front of the machine from a stock, and the lapped papers are fed downwardly, around an exposure drum centrally located in the machine, and upwardly into a separator, from which the original emerges in the front of the machine below the inlet slot. The printing paper sheet is fed downward and rearward through a developing section, when it passes around a drying roller and is fed forward out of the machine at the bottom of the front face thereof.