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公开(公告)号：US11073519B2
公开(公告)日：2021-07-27
申请号：US15300558
申请日：2015-03-17
发明人： Alexander Schenk , Klaus Hochleitner , Suzana Kiel , Marcel Thieme , Wei Sun
IPC分类号： G01N33/558 , G01N33/52
摘要： In a lateral flow test (LFT) device, the liquid conduit element 20 is formed from a substrate 21, 22 or 24 having at least two layers, including a first layer 21b, 22b or 24b not exceeding 75 μm in thickness formed from a porous material for wicking liquid, and a second layer 21a,22a or 24a of additional thickness formed from a generally non-porous polymer material acting as backing layer. The layered arrangement is incorporated into an LFT device to reduce sample volume requirements.
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公开(公告)号：US20210346846A1
公开(公告)日：2021-11-11
申请号：US17286847
申请日：2019-10-31
发明人： Stuart Swinburne , Klaus Gebauer
摘要： Disclosed is a method for the production of a porous polymer membrane suitable for liquid filtration or analyte capture, comprising the steps of: providing a flowable composition (100) on a substrate (220) the composition including at least: photo-activatable monomer molecules, photo activation initiator molecules and photo-activation quencher molecules; providing one or more pulses (L) of laser light at at least one focal point in the composition of sufficient energy to locally polymerise the composition; moving the or each focal point relative to the previously polymerised composition in a continuous or stepwise predetermined manner to a multiplicity of further positions; and repeating the pulse(s) at those further positions such that a three dimensional matrix of the composition is polymerised leaving unpolymerized areas of a size equivalent to conventional polymer membrane pores.
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公开(公告)号：US12017185B2
公开(公告)日：2024-06-25
申请号：US17286847
申请日：2019-10-31
发明人： Stuart Swinburne , Klaus Gebauer
CPC分类号： B01D67/0006 , B01D67/003 , B01D67/0032 , B01D69/125 , B01D69/12 , B01D2323/32 , B01D2323/34 , B01D2323/42 , B01D2323/50 , B01D2325/0283
摘要： Disclosed is a method for the production of a porous polymer membrane suitable for liquid filtration or analyte capture, comprising the steps of: providing a flowable composition (100) on a substrate (220) the composition including at least: photo-activatable monomer molecules, photo activation initiator molecules and photo-activation quencher molecules; providing one or more pulses (L) of laser light at at least one focal point in the composition of sufficient energy to locally polymerise the composition; moving the or each focal point relative to the previously polymerised composition in a continuous or stepwise predetermined manner to a multiplicity of further positions; and repeating the pulse(s) at those further positions such that a three dimensional matrix of the composition is polymerised leaving unpolymerized areas of a size equivalent to conventional polymer membrane pores.
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公开(公告)号：US20240359136A1
公开(公告)日：2024-10-31
申请号：US18560264
申请日：2022-05-09
发明人： Till Briskot , Nils Hillebrandt , Tobias Hahn , Thiemo Huuk , Jürgen Hubbuch
IPC分类号： B01D61/22
CPC分类号： B01D61/22 , B01D2313/701
摘要： In at least one embodiment, the method for monitoring a filtration process in which a first solution is processed by a filter system (100) comprises: —receiving first measurement data which are indicative for at least one input process variable (V1_M, V2_M), wherein the at least one input process variable (V1_M, V2_M) is a process variable of the filtration process measurable during the filtration process with help of a measurement unit (11, 31), —determining output data by executing a filtration process model (4) and using the first measurement data, wherein—executing the filtration process model (4) comprises solving at least one physical equation describing the interaction between solutes of the first solution, —at least one parameter of the filtration process model (4) is dependent on the at least one input process variable (V1_M, V2_M) derived from the first measurement data, —the output data is indicative for at least one modeled process variable (V3_P, V4_P) of the filtration process.
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公开(公告)号：US20230399634A1
公开(公告)日：2023-12-14
申请号：US17793635
申请日：2021-01-19
IPC分类号： C12N15/10 , C12Q1/6806
CPC分类号： C12N15/1013 , C12Q1/6806
摘要： A method for isolating cell-free DNA from liquid body sample, comprising the following steps: a) Providing liquid body sample; b) Adding to said sample: a solid phase capable of binding DNA; a binding buffer comprising a detergent and a chaotropic agent; and 2-propanol, to form a binding mixture thereof; c) Washing the solid phase to remove unbound material; and d) Eluting bound cell-free DNA, wherein the majority of the eluted DNA is
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