公开(公告)号：US08293714B2

公开(公告)日：2012-10-23

申请号：US12432528

申请日：2009-04-29

Applicant: Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

Inventor： Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

IPC: A61K38/16

CPC classification number: A61K47/48215 ,  A61K47/48246 ,  A61K47/48415 ,  A61K47/48507 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6811 ,  A61K47/6835 ,  C07K14/71

Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.

Abstract translation: 本发明提供VEGF结合肽。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。 提供肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。

公开(公告)号：US08288349B2

公开(公告)日：2012-10-16

申请号：US11938766

申请日：2007-11-12

Applicant: Curt William Bradshaw ,  Abhijit Suresh Bhat ,  Jing-Yu Lai ,  Venkata R. Doppalapudi ,  Dingguo Liu

Inventor： Curt William Bradshaw ,  Abhijit Suresh Bhat ,  Jing-Yu Lai ,  Venkata R. Doppalapudi ,  Dingguo Liu

IPC: A61K38/16 ,  A61K51/10 ,  C07K14/515

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/515 ,  C07K2319/30

Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.

Abstract translation: 本发明提供了AA靶向化合物，其包含与抗体的组合位点连接的AA靶向剂 - 接头缀合物。 提供了化合物的各种用途，包括治疗与异常血管发生相关的病症的方法。

公开(公告)号：US08912148B2

公开(公告)日：2014-12-16

申请号：US13584721

申请日：2012-08-13

Applicant: Curt Bradshaw ,  Abhijit Bhat ,  Jing Yu Lai ,  Venkata Doppalapudi ,  Dingguo Liu

Inventor： Curt Bradshaw ,  Abhijit Bhat ,  Jing Yu Lai ,  Venkata Doppalapudi ,  Dingguo Liu

IPC: A61K38/10 ,  C07K14/00 ,  C07K14/515 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61K38/00 ,  C07K14/515 ,  C07K2319/30

Abstract: The present invention provides methods of treating (including preventing) a disease or condition associated with abnormal angiogenesis in a subject include administering a therapeutically effective amount of an AA targeting compound of the invention to the subject. The AA targeting compounds comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody.

Abstract translation: 本发明提供了治疗（包括预防）与受试者异常血管生成相关的疾病或病症的方法，包括向受试者施用治疗有效量的本发明的AA靶向化合物。 AA靶向化合物包含与抗体的结合位点连接的AA靶向剂 - 接头缀合物。