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公开(公告)号：US20250058123A1
公开(公告)日：2025-02-20
申请号：US18939885
申请日：2024-11-07
Inventor： Rosana Esteller , Mahsa Malekmohammadi , Andrew Haddock , Tianhe Zhang
Abstract: Methods and systems are described for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.
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公开(公告)号：US20250050107A1
公开(公告)日：2025-02-13
申请号：US18797122
申请日：2024-08-07
Inventor： Lisa Denise Moore , Peter J. Yoo
IPC: A61N1/36
Abstract: Electrical stimulation systems and methods for operation and management of the electrical stimulation system are described. One method for operation of an electrical stimulation system includes receiving a request to modify stimulation; displaying a graph for at least one adjustable stimulation parameter; indicating on the graph a current setting of each of the at least one adjustable stimulation parameter and a range around the current setting of at least one of the at least one adjustable stimulation parameter which represents at least one of a minor change in the stimulation based on a predefined minor change criteria or a moderate change in the stimulation based on a predefined moderate change criteria; receiving a selection of a new setting for at least one of the at least one adjustable stimulation parameter; and modifying the stimulation according to the selection.
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公开(公告)号：US20250041605A1
公开(公告)日：2025-02-06
申请号：US18784365
申请日：2024-07-25
Inventor： G. Karl Steinke , Tomasz Mark Fraczek
Abstract: Systems and methods for selective sensing of evoked responses (ERs) and using the ERs to guide neuromodulation are disclosed. An exemplary system comprises at least one multi-electrode lead, an electrostimulator to provide electrostimulation to a neural target, a sensing circuit to sense ERs to electrostimulation, and a controller circuit. In response to electrostimulation delivered to the neural target in accordance with a stimulation setting via a stimulating electrode, the controller circuit can collect ERs from each of a group of sensing electrodes selected from and less than an entirety of the electrodes on the lead. The selected electrodes can be distinct from the stimulating electrode, or within a specific proximity to the stimulating electrode. The controller circuit can use a comparison of the sensed ERs to acceptance criterion to aid in lead placement and stimulation programming.
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公开(公告)号：US12214200B2
公开(公告)日：2025-02-04
申请号：US18195690
申请日：2023-05-10
Inventor： Joseph M. Bocek , Michael X. Govea , Rosana Esteller
Abstract: An example of an apparatus for percutaneously delivering neurostimulation energy to a patient and sensing from the patient using a test device placed externally to the patient is provided. The apparatus may include a stimulation lead, a sensing reference electrode, a sensing wire, and a connection system. The stimulation lead may be configured to be percutaneously introduced into the patient to place the one or more electrodes in the patient. The sensing reference electrode may be configured to be placed in the patient. The sensing wire may be connected to the sensing reference electrode and configured to be percutaneously introduced into the patient to place the sensing reference electrode in the patient. The connection system may be configured to mate the lead connector and the wire connector and to provide electrical connections between the lead connector and the test device and between the wire connector and the test device.
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公开(公告)号：US20250025695A1
公开(公告)日：2025-01-23
申请号：US18908610
申请日：2024-10-07
Inventor： Jessica Block , Rosana Esteller
Abstract: A system may include at least one lead, a stimulation waveform generator, and a controller. The controller may be programmed to implement a process to suggest at least one electrode to be used to stimulate the nerve root. A therapeutic window may be determined for each electrode. For each electrode determining the therapeutic window may include applying stimulation, determining a first stimulation threshold for the applied stimulation to cause a first physiological effect, determining a second stimulation threshold for the applied stimulation to cause a second physiological effect, and determining a difference between the first stimulation threshold and the second stimulation threshold, wherein the difference is the therapeutic window. The process may further include determining at electrode(s) with a minimum value for the therapeutic window, and suggesting the electrode(s) to be used to stimulate the nerve root based on the determined electrode(s) with the minimum value.
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Patent Agency Ranking
公开(公告)号：US12201835B2
公开(公告)日：2025-01-21
申请号：US17835389
申请日：2022-06-08
Inventor： Tianhe Zhang , Que T. Doan
Abstract: A system may include electrodes on at least one lead configured to be operationally positioned for use in modulating a volume of neural tissue, a neural modulation generator configured to deliver energy using at least some electrodes to modulate the volume of neural tissue, a programming system configured to program the programmed modulation parameter set, including determine electrode fractionalizations for the electrodes based on a target multipole. The programmed parameter set may include the determined electrode fractionalizations. The target multipole may be used to determine electrode fractionalizations having at least three target poles that directionally and progressively stack fractionalizations of target poles to provide a linear electric field over the volume of tissue. The neural modulation generator may be configured to use the programmed modulation parameter set to provide the linear electric field over the volume of tissue.
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公开(公告)号：US12194291B2
公开(公告)日：2025-01-14
申请号：US17747471
申请日：2022-05-18
Inventor： Arthur J. Foster , Pratap Arangil , Hari Hara Subramanian
Abstract: An electrical stimulation lead includes a cuff having a cuff body having an exterior surface, an interior surface, and a circumference; longitudinally elongated electrodes disposed on the interior surface of the cuff body and helically arranged with each of the longitudinally elongated electrodes longitudinally offset relative to any adjacent longitudinally elongated electrodes; and a longitudinal slit extending through the cuff body and further extending along an entire length of the cuff body, the longitudinal slit operable to receive a portion of a target nerve from a region outside of the cuff to within the cuff body. The lead also includes a lead body coupled to the cuff and conductors extending through the lead body and the cuff with the conductors electrically coupled to the longitudinally elongated electrodes.
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公开(公告)号：US20250001177A1
公开(公告)日：2025-01-02
申请号：US18753832
申请日：2024-06-25
Inventor： Leon Juarez Paz
Abstract: A method for optimizing stimulation for a patient having a stimulator device such as a Deep Brain Stimulation (DBS) device is disclosed, which involves a consideration of tissue imaging information in the environment around the lead. Test stimulation is provided at initial combinations of lead positions and values of a stimulation parameter such as amplitude, with patient results scored for each combination. One or more objective criteria are measured and scored. The objective criteria may be electrode impedances and/or indicators of stress, such as cardiac signals. This process repeats iteratively until a stopping criterium is met. The lead positions in question may be longitudinal or rotational positions around the lead, and preferably both if the lead is directional in nature.
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公开(公告)号：US12172001B2
公开(公告)日：2024-12-24
申请号：US17662788
申请日：2022-05-10
Inventor： Hemant Bokil
Abstract: Methods of providing electrical neural modulation to a patient's brain are disclosed herein. The methods involve differentially modulating two or more target regions of the brain. For example, a first target region may be provided with an electrical neural modulation signal that activates that target region while a second target region is provided with an electrical neural modulation signal that suppresses or deactivates that target region. As the implantable pulse generators (IPGs) described herein include independent current sources, such differential modulation can be provided with a single IPG.
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10.发明申请公开(公告)号：US20240408395A1
公开(公告)日：2024-12-12
申请号：US18808919
申请日：2024-08-19
Inventor： Tianhe Zhang , Michael A. Moffitt , Que Doan
Abstract: New waveforms for use in an implantable pulse generator or external trial stimulator are disclosed which mimic actively-driven biphasic pulses, and which are particularly useful for providing sub-perception Spinal Cord Stimulation therapy using low frequency pulses. The waveforms comprise anodic and cathodic pulses which are effectively monophasic in nature, although low-level, non-therapeutic charge recovery can also be used.
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