公开(公告)号：US20060234959A1

公开(公告)日：2006-10-19

申请号：US11107105

申请日：2005-04-14

申请人： Merrill Biel ,  Chester Sievert ,  Mark Peterson

发明人： Merrill Biel ,  Chester Sievert ,  Mark Peterson

IPC分类号： A61K31/7048 ,  A61K31/14 ,  A61H33/00

CPC分类号： A61N5/062 ,  A61K31/14 ,  A61K31/7048

摘要： A method of photodynamic disruption of target cells within a target cell site wherein the target cells are associated with one or more of a sterilization procedure, a biofilm eradication procedure, a sterilization procedure of a medical prosthesis, a treatment of an infection at a tissue site, eradication of cancer cells and a fluid or food decontamination process. Surface acting agents such as benzalkonium chloride or polymyxin B sulfate or both may be utilized. A controllable light source capable of delivering light at a plurality of duty cycles is utilized to cause photoactivation of the photosensitive material resulting in degradation of target cells within the site.

摘要翻译： 靶细胞位点内靶细胞的光动力学破坏的方法，其中靶细胞与消毒过程，生物膜根除程序，医用假体的消毒程序，组织部位感染的治疗中的一个或多个相关联 ，根除癌细胞和流体或食物去污过程。 可以使用表面活性剂如苯扎氯铵或多粘菌素B硫酸盐或两者。 利用能够以多个占空比递送光的可控光源，以引起感光材料的光活化，导致位点内目标细胞的降解。

公开(公告)号：US6083487A

公开(公告)日：2000-07-04

申请号：US139481

申请日：1998-08-25

申请人： Merrill A. Biel

发明人： Merrill A. Biel

IPC分类号： A61B17/00 ,  A61N5/06 ,  G01N21/64 ,  A61B10/00 ,  G01N21/76

CPC分类号： G01N21/6428 ,  A61B2017/00057 ,  A61N2005/0645 ,  A61N2005/0652 ,  A61N5/0603 ,  G01N2021/6439 ,  Y10S436/80

摘要： A method for differentiating between normal tissue and tumor tissue within a tissue field. The method includes the application of a photosensitizer solution to the tissue field and the subsequent illumination and measurement of fluorescent intensity across the tissue field. The measurement of relative fluorescent intensity across the tissue field provides information relating to the existence or nonexistence of tumor tissue. Solution concentrations of methylene blue and or toluidene blue are utilized to provide the greatest differentiability between normal tissue and tumor tissue within the tissue field.

摘要翻译： 用于区分组织区域内的正常组织和肿瘤组织的方法。 该方法包括将光敏剂溶液应用于组织场，随后照射和测量穿过组织场的荧光强度。 跨组织场的相对荧光强度的测量提供了与肿瘤组织的存在或不存在有关的信息。 亚甲基蓝和/或甲苯蓝的溶液浓度用于提供组织场内正常组织和肿瘤组织之间的最大差异性。

公开(公告)号：US08267982B2

公开(公告)日：2012-09-18

申请号：US09792578

申请日：2001-02-23

申请人： Merrill A. Biel

发明人： Merrill A. Biel

IPC分类号： A61N5/06

CPC分类号： A61K41/0076 ,  A61K31/54 ,  A61K41/0019 ,  A61K41/0057 ,  A61K41/0071 ,  A61K31/185 ,  A61K2300/00

摘要： The invention relates to a method of photoeradication of cellular and acellular organisms including the steps of providing a surface acting agent in association with a cellular or acellular organism, the surface acting agent disorienting a membrane structure so that said membrane no longer functions as an effective osmotic barrier; providing a photosensitive material in association with the cellular or acellular organism; and applying light in association with the cellular or acellular organism to cause a disruption of the organism. The method according to the present invention may be utilized in invitro and invivo treatment protocols for infections, sterilization procedures, cancer cell eradication, virus and fungus eradication, spore eradication, and biofilm organism eradication. Additional aspects of the invention include particular combinations of photosensitive materials and surfactants for use in photodynamic therapies.

摘要翻译： 本发明涉及细胞和非细胞生物的光泽化方法，包括以下步骤：提供与细胞或细胞生物体相关的表面作用剂，表面作用剂使膜结构失调，使得所述膜不再起到有效的渗透作用 屏障; 提供与细胞或无细胞生物相关的感光材料; 并且与细胞或细胞生物体相关联地施加光以引起生物体的破坏。 根据本发明的方法可以用于感染，灭菌程序，癌细胞根除，病毒和真菌根除，根除细菌和生物膜生物根除的invitro和invivo治疗方案。 本发明的另外的方面包括用于光动力疗法的感光材料和表面活性剂的特定组合。

公开(公告)号：US07862219B2

公开(公告)日：2011-01-04

申请号：US12288649

申请日：2008-10-22

申请人： Steven H. Mersch ,  Ronald R. Zimmermann ,  Merrill A. Biel

发明人： Steven H. Mersch ,  Ronald R. Zimmermann ,  Merrill A. Biel

IPC分类号： F21V7/04

CPC分类号： G02B6/001 ,  A61B5/0059 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/062

摘要： A light diffusing device for use in photodynamic therapy has a progressively distally increased exposed amount of core fiber defining a light emitting section. Excessive light energy emission is thus prevented access to proximal locations and provides an increased amount of available light energy at distal locations, thus permitting an even emission of light energy along the light emitting section.

摘要翻译： 用于光动力疗法的光漫射装置具有逐渐增加的限定发光部分的芯纤维的暴露量。 因此，过度的光能发射被阻止进入近端位置，并且在远端位置处提供增加的可用光能量，从而允许沿着发光部分均匀地发射光能。

公开(公告)号：US6159236A

公开(公告)日：2000-12-12

申请号：US239353

申请日：1999-01-28

申请人： Merrill A. Biel

发明人： Merrill A. Biel

IPC分类号： A61B18/22 ,  A61F2/958 ,  A61N5/06 ,  A61B18/18 ,  A61N1/30

CPC分类号： A61N5/062 ,  A61M25/10 ,  A61N5/0601 ,  A61B2018/2261 ,  A61M2205/051 ,  A61M2205/587 ,  A61N2005/0609

摘要： The invention relates to a medical device including a tube and expandable member and one or more light sources disposed in an elongated member disposed in the tube. The light sources emit energy for photodynamic therapy through a window to the treatment area. The treatment device may further include a heat and/or light dissipating layer, such as a layer of gold alloy paint, or other light blocking material.

摘要翻译： 本发明涉及一种包括管和可扩张构件的医疗装置以及设置在管中的细长构件中的一个或多个光源。 光源通过窗口向治疗区域发射光动力治疗的能量。 治疗装置还可以包括加热和/或光消散层，例如金合金涂层或其它阻光材料。

公开(公告)号：US6048359A

公开(公告)日：2000-04-11

申请号：US139862

申请日：1998-08-25

申请人： Merrill A. Biel

发明人： Merrill A. Biel

IPC分类号： A61B17/00 ,  A61N5/06 ,  G01N21/64 ,  A61N5/01

CPC分类号： A61N5/0601 ,  A61N5/062 ,  A61B2017/00057 ,  A61N2005/0645 ,  A61N2005/0652 ,  A61N5/0603

摘要： A medical apparatus including implantable elongate probes for emitting diffused light energy within the interior of a tissue body to provide a uniform light dosage to the tissue body. In one particular embodiment, the probes may include a plurality of LEDs or VSCEL devices interspaced along the probe shaft. The invention further provides an planar or shaped alignment grid for aligning one or more probes within the tissue body.

摘要翻译： 一种医疗设备，包括可植入细长探针，用于在组织体内部发射扩散的光能以对组织体提供均匀的光剂量。 在一个具体实施例中，探针可以包括沿着探针轴间隔开的多个LED或VSCEL装置。 本发明进一步提供了用于对准组织体内的一个或多个探针的平面或成形的对准网格。

公开(公告)号：US08187278B2

公开(公告)日：2012-05-29

申请号：US10026198

申请日：2001-12-21

申请人： Merrill A. Biel

发明人： Merrill A. Biel

IPC分类号： A61N5/06

CPC分类号： A61K41/0076 ,  A61K31/54 ,  A61K41/0019 ,  A61K41/0057 ,  A61K41/0071 ,  A61K2300/00

摘要： The invention relates to a method of photoeradication of cellular and acellular organisms including the steps of providing a surface acting agent containing benzalkonium chloride in association with a cellular or acellular organism, the surface acting agent disorienting a membrane structure so that said membrane no longer functions as an effective osmotic barrier; providing a photosensitive material in association with the cellular or acellular organism; and applying light in association with the cellular or acellular organism to cause a disruption of the organism. The method according to the present invention may be utilized in invitro and invivo treatment protocols for infections, sterilization procedures, cancer cell eradication, virus and fungus eradication, spore eradication, and biofilm organism eradication. Additional aspects of the invention include particular combinations of photosensitive materials and surfactants for use in photodynamic therapies.

摘要翻译： 本发明涉及一种细胞和非细胞生物的光泽化方法，包括以下步骤：提供含有与杀菌细胞或细胞生物体结合的苯扎氯铵的表面活性剂，所述表面作用剂使膜结构失调，使得所述膜不再起到 有效的渗透屏障; 提供与细胞或无细胞生物相关的感光材料; 并且与细胞或细胞生物体相关联地施加光以引起生物体的破坏。 根据本发明的方法可以用于感染，灭菌程序，癌细胞根除，病毒和真菌根除，根除细菌和生物膜生物根除的invitro和invivo治疗方案。 本发明的另外的方面包括用于光动力疗法的感光材料和表面活性剂的特定组合。

公开(公告)号：US20120029418A1

公开(公告)日：2012-02-02

申请号：US13190857

申请日：2011-07-26

申请人： Merrill Biel

发明人： Merrill Biel

IPC分类号： A61M37/00 ,  A61K31/5415 ,  A61L2/00 ,  A61K31/197

CPC分类号： A61K31/198 ,  A61K31/5415 ,  A61K2300/00

摘要： The present invention includes a composition for photoablation comprising a photosensitizer and ethylenediaminetetraacetic acid (“EDTA”) at a very low concentration (e.g., ranging from about 0.01 mM to about 1.25 mM), wherein the composition is used for photoablation of at least one targeted organism. The present invention also includes a method for photoablation comprising applying the composition to a treatment site containing at least one targeted organism and applying light to the treatment site at a wavelength absorbed by the photosensitizer so as to inhibit the at least one targeted organism.

摘要翻译： 本发明包括用于光解作用的组合物，其包含非常低浓度（例如约0.01mM至约1.25mM）的光敏剂和乙二胺四乙酸（“EDTA”），其中该组合物用于至少一种靶向 生物。 本发明还包括一种光消除的方法，包括将组合物施用于含有至少一种靶向生物体的处理部位，并以由光敏剂吸收的波长向处理部位施加光，以抑制至少一种靶向生物体。

公开(公告)号：US20060173514A1

公开(公告)日：2006-08-03

申请号：US11050349

申请日：2005-02-02

申请人： Merrill Biel ,  Chester Sievert

发明人： Merrill Biel ,  Chester Sievert

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61F13/023 ,  A61F2013/00187 ,  A61F2013/00523 ,  A61F2013/00646 ,  A61F2013/0091 ,  A61F2013/00919 ,  A61K9/0009 ,  A61K9/703 ,  A61K9/7084 ,  A61K41/0057 ,  A61N1/30 ,  A61N2005/0628 ,  A61N2005/0645 ,  A61N2005/0652

摘要： The invention relates to a light emitting treatment device including one or more light members, which are configured to emit light energy for the purpose of performing localized photodynamic therapy at a targeted field. The light members may be disposed in a substantially uniform array and be configured to emit energy in a substantially uniform pattern. The light treatment device has a self-contained energy supply. The light emitting treatment device may be controlled to deliver one or more various light doses and dose rates at various light frequencies per treatment. The treatment device may be made of a polymeric material configured to conform to a body surface. The treatment device may contain the photosensitizer. The light emitting treatment device may further include a heat dissipating layer such as a layer of gold or gold alloy, or a layer of adhesive disposed on at least one of the one or more surfaces. Methods of using the treatment device are also disclosed.

摘要翻译： 本发明涉及包括一个或多个光部件的发光处理装置，其被配置为发射光能以在目标场进行局部光动力学治疗。 光构件可以以基本均匀的阵列布置并且被配置为以基本均匀的图案发射能量。 光处理装置具有独立的能量供应。 可以控制发光处理装置以每次处理以各种光频率递送一种或多种各种光剂量和剂量率。 治疗装置可以由构造成符合身体表面的聚合物材料制成。 治疗装置可以含有光敏剂。 发光处理装置还可以包括散热层，例如金或金合金层，或者设置在一个或多个表面中的至少一个上的粘合剂层。 还公开了使用治疗装置的方法。

公开(公告)号：US07070611B2

公开(公告)日：2006-07-04

申请号：US10208632

申请日：2002-07-29

申请人： Merrill A. Biel

发明人： Merrill A. Biel

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61B2017/00057 ,  A61N5/062 ,  A61N2005/005 ,  A61N2005/007 ,  A61N2005/0606 ,  A61N2005/0645 ,  A61N2005/0652

摘要： The invention relates to a light emitting treatment device including one or more light members which are configured to emit energy for photodynamic therapy at a treatment field. The treatment device may be made of a polymeric material configured to conform to a body surface. The light members may be disposed in a substantially uniform array and be configured to emit energy in a substantially uniform pattern. The light emitting treatment device may provide light variable feedback to a control apparatus. The light emitting treatment device may further include a heat dissipating layer, a layer of gold or gold alloy, or a layer of adhesive disposed on at least one of the one or more surfaces. Methods of using the treatment device are also disclosed.