公开(公告)号：US20200283751A1

公开(公告)日：2020-09-10

申请号：US16842200

申请日：2020-04-07

Applicant: aTyr Pharma Inc.

Inventor： Chi-Fang WU ,  Darin LEE ,  Jeffry D. WATKINS ,  Kristi PIEHL ,  Kyle P. CHIANG ,  Marc THOMAS ,  Minh-Ha DO ,  Ying BUECHLER ,  John D. MENDLEIN

IPC: C12N9/00 ,  C12N9/96 ,  A61P37/00 ,  A61P11/00 ,  A61P29/00

Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.

公开(公告)号：US20220098568A1

公开(公告)日：2022-03-31

申请号：US17344154

申请日：2021-06-10

Applicant: aTyr Pharma, Inc.

Inventor： Chi-Fang WU ,  Darin LEE ,  Jeffry D. WATKINS ,  Kristi PIEHL ,  Kyle CHIANG ,  Marc THOMAS ,  Minh-Ha DO ,  Ying BUECHLER ,  John D. MENDLEIN

IPC: C12N9/00 ,  C12N9/96 ,  A61P37/00 ,  A61P11/00 ,  A61P29/00

Abstract: The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions. The HRS-Fc conjugates of the invention have improved controlled release properties, stability, half-life, and other pharmacokinetic and biological properties relative to corresponding, unmodified HRS polypeptides.