公开(公告)号：US20240092917A1

公开(公告)日：2024-03-21

申请号：US18477113

申请日：2023-09-28

Applicant: aTyr Pharma, Inc.

Inventor： Luke BURMAN ,  Yeeting CHONG ,  Leslie Ann GREENE ,  David KING ,  Zhiwen XU ,  Ryan Andrew ADAMS

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04

CPC classification number: C07K16/2863 ,  A61K39/3955 ,  A61P35/00 ,  A61P35/04 ,  A61K2039/505

Abstract: Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.

公开(公告)号：US20210163606A1

公开(公告)日：2021-06-03

申请号：US17062100

申请日：2020-10-02

Applicant: aTyr Pharma, Inc.

Inventor： Luke BURMAN ,  Yeeting CHONG ,  Leslie Ann GREENE ,  David KING ,  Zhiwen XU ,  Ryan Andrew ADAMS

IPC: C07K16/28 ,  A61K33/243 ,  A61K39/395 ,  A61P35/00 ,  A61P35/04 ,  A61K31/513

Abstract: Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.