公开(公告)号：US20190113528A1

公开(公告)日：2019-04-18

申请号：US16099822

申请日：2017-05-09

申请人： Yasuhiro Hashimoto ,  FUKUSHIMA MEDICAL UNIVERSITY

发明人： Yasuhiro HASHIMOTO ,  Kyoka HOSHI ,  Hiromi ITO ,  Takashi HONDA ,  Yoshiki YAMAGUCHI ,  Masamichi NAGAE

IPC分类号： G01N33/68 ,  C07K14/79

摘要： An object of the present invention is to develop a biomarker for discriminating dementia, particularly, Alzheimer's disease and mild cognitive impairment which can progress to Alzheimer's disease, from other central nervous system diseases, or capable of determining a pathological condition of dementia, and provide a method for diagnosing dementia early and a method for determining a pathological condition of dementia, using the biomarker. A transferrin glycoprotein containing a glycan having at least one mannose at a non-reducing end or a transferrin fragment containing the glycan is used as a diagnostic marker for Alzheimer's disease.