公开(公告)号：US10562865B2

公开(公告)日：2020-02-18

申请号：US16359984

申请日：2019-03-20

Applicant: YUHAN CORPORATION

Inventor： Tae Dong Han ,  Hee Jae Tak ,  Eun Kyung Kim ,  Su Bin Choi ,  Dong Hoon Kim ,  Sol Park ,  Eun Hye Jung ,  Hyun Ho Choi ,  Tae Wang Kim ,  Mi Kyeong Ju ,  Na Ry Ha

IPC: C07D401/04 ,  C07D401/14 ,  C07D249/12 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14 ,  C07D249/08 ,  C07D403/04 ,  C07D417/04 ,  C07D407/14 ,  C07D401/10 ,  C07D405/14 ,  C07D413/14

Abstract: The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

公开(公告)号：US11492335B2

公开(公告)日：2022-11-08

申请号：US17104557

申请日：2020-11-25

Applicant: YUHAN CORPORATION

Inventor： Tae Dong Han ,  Hee Jae Tak ,  Eun Kyung Kim ,  Su Bin Choi ,  Dong Hoon Kim ,  Sol Park ,  Eun Hye Jung ,  Hyun Ho Choi ,  Tae Wang Kim ,  Mi Kyeong Ju ,  Na Ry Ha

IPC: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D409/10 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D249/08 ,  C07D401/04 ,  C07D405/10 ,  C07D407/14 ,  C07D401/10 ,  C07D403/10 ,  C07D405/14 ,  C07D413/10 ,  C07D417/10 ,  C07D249/12

Abstract: The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

公开(公告)号：US11655235B2

公开(公告)日：2023-05-23

申请号：US17090552

申请日：2020-11-05

Applicant: YUHAN CORPORATION

Inventor： Tae Han Dong ,  Yoo Hoi Park ,  Tae Kyun Kim ,  Jae Eun Joo ,  Eun Hye Jung ,  Jae Won Jeong ,  Hyun Seung Lee ,  Do Hoon Kim ,  Ji Eun Yang ,  Jun Chui Park ,  Sang Myoun Lim ,  Na Ry Ha ,  Da In Chung ,  Ji Yeong Gal

IPC: A61P1/16 ,  A61P35/00 ,  C07D207/16 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/4725 ,  A61K31/519 ,  A61K31/423 ,  A61K31/517 ,  A61K31/4365 ,  A61K31/4025 ,  A61K31/4355

CPC classification number: C07D401/14 ,  C07D207/16 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/4025 ,  A61K31/423 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P1/16 ,  A61P35/00

Abstract: The present technology provides pyrrolidine and piperidine compounds or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. In particular, said compounds may be usefully applied in the treatment and prevention of FAP-mediated diseases.

公开(公告)号：US20210147386A1

公开(公告)日：2021-05-20

申请号：US17090552

申请日：2020-11-05

Applicant: YUHAN CORPORATION

Inventor： Tae Han DONG ,  Yoo Hoi PARK ,  Tae Kyun KIM ,  Jae Eun JOO ,  Eun Hye Jung ,  Jae Won JEONG ,  Hyun Seung LEE ,  Do Hoon KIM ,  Ji Eun YANG ,  Jun Chul PARK ,  Sang Myoun LIM ,  Na Ry HA ,  Da In CHUNG ,  Ji Yeong GAL

IPC: C07D401/14 ,  C07D409/14 ,  C07D405/14 ,  C07D491/048 ,  C07D207/16 ,  C07D495/04 ,  C07D403/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present technology provides pyrrolidine and piperidine compounds or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and uses thereof. In particular, said compounds may be usefully applied in the treatment and prevention of FAP-mediated diseases.

公开(公告)号：US10899719B2

公开(公告)日：2021-01-26

申请号：US16721020

申请日：2019-12-19

Applicant: YUHAN CORPORATION

Inventor： Tae Dong Han ,  Hee Jae Tak ,  Eun Kyung Kim ,  Su Bin Choi ,  Dong Hoon Kim ,  Sol Park ,  Eun Hye Jung ,  Hyun Ho Choi ,  Tae Wang Kim ,  Mi Kyeong Ju ,  Na Ry Ha

IPC: C07D403/04 ,  C07D249/08 ,  C07D401/04 ,  C07D417/04 ,  C07D409/10 ,  C07D405/10 ,  C07D407/14 ,  C07D401/10 ,  C07D403/10 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  C07D413/10 ,  C07D417/10 ,  C07D249/12 ,  C07D403/14

Abstract: The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).