公开(公告)号：US3573309A

公开(公告)日：1971-03-30

申请号：US3573309D

申请日：1968-07-30

申请人： YISSUM RES DEV CO

发明人： BERGMANN FELIX GOTTHILF ,  KLEINER MORDECHAI ABRAHAM ,  RASHI MOSHE

IPC分类号： C07D473/00 ,  C07D473/04 ,  C07D473/30 ,  C07D473/38 ,  C07D57/62

CPC分类号： C07D473/38 ,  C07D473/00 ,  C07D473/04 ,  C07D473/30

摘要： 8-PYRIDLY PURINES CAN BE SYNTHESIZED BY CONDENSATION OF 4,5-DIAMINOPYRIMIDINES WITH AMIDINOPYRIDINES. PROTONATION OF THE PYRIDINE NITROGEN CAUSES A MARKED BATHOCHROMIC SHIFT OF $MAX IN THE 2- AND 4-PYRIDYL DERIVATIVES, BUT NOT IN THE 3-PYRIDYL ISOMERS. A SIMILAR EFFECT IS PRODUCED BY QUATERNISATION OF THE 4-, BUT NOT OF THE 3-PRIDYL SUBSTITUENT. THE 8-(N-METHYLPYRIDINIUM) GROUP ALSO FACILITATES GREATLY ANION FORMATION IN THE PRUINE RING. THE NEW COMPOUNDS SHOWED A VARIETY OF BIOLOGICAL ACTIVITIES, SUCH AS PROLONGED HYPOTENSION WHEN INJECTED INTO CATS WHICH WERE ANESTHETIZED WITH NEMBUTAL.