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公开(公告)号:US20130267456A1
公开(公告)日:2013-10-10
申请号:US13822173
申请日:2011-09-21
申请人: Xiao-jing WANG , Yosef REFAELI , Qinghong ZHANG
发明人: Xiao-jing WANG , Yosef REFAELI , Qinghong ZHANG
IPC分类号: A61K38/00 , A61K45/06 , A61K31/7088
CPC分类号: A61K38/1709 , A61K31/7088 , A61K38/00 , A61K38/162 , A61K38/18 , A61K45/06 , C07K14/4703 , C07K2319/09 , C12N7/00 , C12N2740/16033
摘要: The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to mucositis.
摘要翻译: 本发明提供了用于治疗炎症和/或组织损伤病症的方法和组合物。 特别地,描述了局部或全身地递送到炎症和/或组织损伤部位的Smad7组合物的使用。 其它具体实施方案涉及治疗或预防由辐射和/或化疗引起的副作用,包括但不限于粘膜炎。