公开(公告)号：US20240301093A1

公开(公告)日：2024-09-12

申请号：US18569673

申请日：2022-06-14

Applicant: William Marsh Rice University

Inventor： David ZHANG ,  Ping SONG ,  Omid VEISEH ,  Siavash PARKHIDEH ,  Sudip MUKHERJEE ,  Maria Isabel RUOCCO ,  Boram KIM ,  Michael David DOERFERT ,  Yuxuan CHENG

IPC: C08B37/00 ,  A61K9/48 ,  A61K35/39 ,  A61K35/51 ,  A61L27/34 ,  A61L27/38 ,  A61L29/08 ,  C12Q1/6881

CPC classification number: C08B37/0084 ,  A61K9/4816 ,  A61K35/39 ,  A61K35/51 ,  A61L27/34 ,  A61L27/3804 ,  A61L29/085 ,  C12Q1/6881 ,  A61L2400/02

Abstract: Disclosed herein are compounds of the formula: A-L-R1(I), wherein the these variables are defined herein, as well as medical devices comprising said compounds. The present disclosure also provides pharmaceutical compositions comprising the compounds or medical devices disclosed herein. Further, the present disclosure provides methods of treatment using the compounds, medical devices, or pharmaceutical compositions disclosed herein.

公开(公告)号：US20230120072A1

公开(公告)日：2023-04-20

申请号：US17787290

申请日：2020-12-18

Applicant: William Marsh Rice University

Inventor： David ZHANG ,  Ruojia WU ,  Peng DAI ,  Yuxuan CHENG ,  Xiangjiang WANG

IPC: C12Q1/6874

Abstract: Provided herein are hybrid capture-based methods to extract single-stranded DNA or RNA directly from non-treated biospecimens. The methods allow for the detection and analysis of unexplored short single-stranded DNA (sssDNA, mean length 50 nt) and ultrashort single-stranded DNA (ussDNA, mean length 15 nt) of human origin present in the biospecimen. The methods allow the discovery of unexplored short single-stranded DNA (sssDNA) in isolated red blood cells, which were believed to be deprived of nucleic acids because of the lack of a nucleus in mature red blood cells. The DNA or RNA extracted using the disclosed methods can be used as disease prognostic biomarkers and treatment predictive biomarkers.

公开(公告)号：US20230054899A1

公开(公告)日：2023-02-23

申请号：US17758828

申请日：2021-01-14

Applicant: William Marsh Rice University

Inventor： David Yu ZHANG ,  Ping SONG ,  Omid VEISEH ,  Siavash PARKHIDEH ,  Sudip MUKHERJEE ,  Maria Isabel RUOCCO ,  Boram KIM ,  Yuxuan CHENG

IPC: C12N5/00 ,  C12N15/10 ,  A61K49/00 ,  A61K9/50 ,  A61K35/39

Abstract: Provided herein are high-throughput methods for genetic barcoding and analysis, e.g., for tagging each biomaterial apsule with a barcode cell. These barcode cells are derived from patient samples, and thus embody natural human genetic variation. Also provided are SNP panels that can be used as genetic barcodes to identify the identity of a cell.

公开(公告)号：US20220411863A1

公开(公告)日：2022-12-29

申请号：US17779689

申请日：2020-11-25

Applicant: William Marsh Rice University

Inventor： David Yu ZHANG ,  Deepak THIRUNAVUKARASU ,  Yuxuan CHENG ,  Ping SONG

IPC: C12Q1/6869

Abstract: Provided herein are compositions and methods for assembling multiple DNA molecules into a linear concatemer, with applications to nanopore sequencing of DNA sequence variations.